Micro-CT imaging of Randall’s plaques

James Williams, James E. Lingeman, Fredric L. Coe, Elaine M. Worcester, Andrew Evan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Micro-computed tomographic imaging (micro-CT) provides unprecedented information on stone structure and mineral composition. High-resolution micro-CT even allows visualization of the lumens of tubule and/or vessels within Randall’s plaque, on stones or in papillary biopsies, thus giving a non-destructive way to study these sites of stone adhesion. This paper also shows an example of a stone growing on a different anchoring mechanism: a mineral plug within the lumen of a Bellini duct (BD plug). Micro-CT shows striking structural differences between stones that have grown on Randall’s plaque and those that have grown on BD plugs. Thus, Randall’s plaque can be distinguished by micro-CT, and this non-destructive method shows great promise in helping to elucidate the different mechanisms by which small stones are retained in the kidney during the development of nephrolithiasis.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalUrolithiasis
Volume43
Issue number1
DOIs
StatePublished - 2014

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Minerals
Nephrolithiasis
Kidney
Biopsy

Keywords

  • Computed tomography
  • Imaging
  • Kidney stones
  • Nephrolithiasis

ASJC Scopus subject areas

  • Urology

Cite this

Micro-CT imaging of Randall’s plaques. / Williams, James; Lingeman, James E.; Coe, Fredric L.; Worcester, Elaine M.; Evan, Andrew.

In: Urolithiasis, Vol. 43, No. 1, 2014, p. 13-17.

Research output: Contribution to journalArticle

Williams, J, Lingeman, JE, Coe, FL, Worcester, EM & Evan, A 2014, 'Micro-CT imaging of Randall’s plaques', Urolithiasis, vol. 43, no. 1, pp. 13-17. https://doi.org/10.1007/s00240-014-0702-z
Williams, James ; Lingeman, James E. ; Coe, Fredric L. ; Worcester, Elaine M. ; Evan, Andrew. / Micro-CT imaging of Randall’s plaques. In: Urolithiasis. 2014 ; Vol. 43, No. 1. pp. 13-17.
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