Micro-CT imaging of Randall’s plaques

James C. Williams, James E. Lingeman, Fredric L. Coe, Elaine M. Worcester, Andrew P. Evan

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Micro-computed tomographic imaging (micro-CT) provides unprecedented information on stone structure and mineral composition. High-resolution micro-CT even allows visualization of the lumens of tubule and/or vessels within Randall’s plaque, on stones or in papillary biopsies, thus giving a non-destructive way to study these sites of stone adhesion. This paper also shows an example of a stone growing on a different anchoring mechanism: a mineral plug within the lumen of a Bellini duct (BD plug). Micro-CT shows striking structural differences between stones that have grown on Randall’s plaque and those that have grown on BD plugs. Thus, Randall’s plaque can be distinguished by micro-CT, and this non-destructive method shows great promise in helping to elucidate the different mechanisms by which small stones are retained in the kidney during the development of nephrolithiasis.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalUrolithiasis
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Computed tomography
  • Imaging
  • Kidney stones
  • Nephrolithiasis

ASJC Scopus subject areas

  • Urology

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