Micro RNA in inflammatory bowel disease: Translational research and clinical implication

Kurt Fisher, Jingmei Lin

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Idiopathic inflammatory bowel disease (IBD) predominantly includes ulcerative colitis and Crohn's disease. The pathogenesis of IBD is complex and not completely understood. MicroRNAs belong to a class of noncoding small RNAs that post-transcriptionally regulate gene expression. Unique microRNA expression profiles have been explored in IBD. In this review, we focus on the unique microRNA expression pattern in both tissue and peripheral blood from IBD patients and emphasize the potential diagnostic and therapeutic applications. The discovery of microRNAs has contributed to our understanding of IBD pathogenesis and might lead to clinical advance in new therapeutics.

Original languageEnglish (US)
Pages (from-to)12274-12282
Number of pages9
JournalWorld Journal of Gastroenterology
Volume21
Issue number43
DOIs
StatePublished - Nov 21 2015

Keywords

  • Crohn's disease
  • Gene expression
  • Inflammatory bowel disease
  • MicroRNA
  • Pathogenesis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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