Micro RNA sequencing for myocardial infarction screening

Sri Harsha Kanuri, Rolf P. Kreutz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

With an increasing life time risk of developing coronary artery disease, and associated mortality in patients greater than 40 years, earlier diagnosis is essential for administering personalized therapy based on their risk status. Despite secondary preventive therapy, a significant proportion of coronary artery disease patients develop subsequent events, with recurrent hospitalizations and associated mortality. Recently, miRNAs have been considered as biomarkers for diagnosis of unstable angina and myocardial infarction, due to their favorable features such as cardiac tissue specificity, rapid release kinetics, and stability in blood. Studies have revealed that miRNAs are involved in underlying pathogenic mechanisms, such as autophagy, endothelial reticulum stress response, atherosclerosis, cardiomyocyte apoptosis, and left ventricular remodeling. Few important miRNAs such as miR-1, miR-133a, miR-133b, miR-208a, miR-208b, and miR-499 have been considered for diagnostic and prognostic purposes of acute myocardial infarction, in recently conducted clinical studies. To be useful as reliable biomarkers, future research is needed in areas of miRNA regulation, targets, and function. Currently available tests for quantification of miRNA are very time-consuming, and a rapid and convenient test is needed.

Original languageEnglish (US)
Title of host publicationPrecision Medicine for Investigators, Practitioners and Providers
PublisherElsevier
Pages187-198
Number of pages12
ISBN (Electronic)9780128191781
DOIs
StatePublished - Jan 1 2019

Keywords

  • Coronary artery disease
  • Coronary biomarkers
  • Coronary plaques
  • Coronary prognosis
  • Endothelial function
  • Gene polymorphisms
  • Metabolic disease
  • Micro RNA
  • Mirna
  • Myocardial infarction
  • Ventricular remodeling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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