Microbubbles during tissue treatment using high intensity focused ultrasound

N. T. Sanghvi, F. J. Fry, Richard Bihrle, Richard Foster, M. H. Phillips, J. Syrus, A. Zaitsev, C. Hennige

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

Based on our previous animal experiments in the treatment of dog prostates and data from others, we selected HIFU parameters, (i.e. focal intensity, Isptp ≈ 1680 W/cm2, frequency = 4 MHz and treatment exposure time = 4 On / 12 Off sec.), to produce thermally induced focal lesions. Using the same acoustic parameters, patient treatment for the Benign Prostatic Hyperplasia (BPH) was commenced in 1992. During the treatment, in some patients, microbubble initiation at the focal site was observed. These microbubbles migrated towards the ultrasound near field as the HIFU procedure continued. To elucidate the similar response, animal experiments were carried out. This paper describes initiation of microbubbles at the focal site followed by their proliferation in the dog prostate during the treatment and finally their effects on tissue lesions. The microbubbles were observed by ultrasound imaging and monitored by subharmonics and broadband signals on the frequency spectrum analyzer. The temperature at the rectal wall was measured to observe and follow the effects of microbubbles in - vivo.

Original languageEnglish
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
PublisherIEEE
Pages1571-1574
Number of pages4
Volume2
StatePublished - 1995
EventProceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2) - Seattle, WA, USA
Duration: Nov 7 1995Nov 10 1995

Other

OtherProceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2)
CitySeattle, WA, USA
Period11/7/9511/10/95

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Animals
Ultrasonics
Patient treatment
Tissue
Spectrum analyzers
Acoustics
Experiments
Imaging techniques
Temperature

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sanghvi, N. T., Fry, F. J., Bihrle, R., Foster, R., Phillips, M. H., Syrus, J., ... Hennige, C. (1995). Microbubbles during tissue treatment using high intensity focused ultrasound. In Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1571-1574). IEEE.

Microbubbles during tissue treatment using high intensity focused ultrasound. / Sanghvi, N. T.; Fry, F. J.; Bihrle, Richard; Foster, Richard; Phillips, M. H.; Syrus, J.; Zaitsev, A.; Hennige, C.

Proceedings of the IEEE Ultrasonics Symposium. Vol. 2 IEEE, 1995. p. 1571-1574.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sanghvi, NT, Fry, FJ, Bihrle, R, Foster, R, Phillips, MH, Syrus, J, Zaitsev, A & Hennige, C 1995, Microbubbles during tissue treatment using high intensity focused ultrasound. in Proceedings of the IEEE Ultrasonics Symposium. vol. 2, IEEE, pp. 1571-1574, Proceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2), Seattle, WA, USA, 11/7/95.
Sanghvi NT, Fry FJ, Bihrle R, Foster R, Phillips MH, Syrus J et al. Microbubbles during tissue treatment using high intensity focused ultrasound. In Proceedings of the IEEE Ultrasonics Symposium. Vol. 2. IEEE. 1995. p. 1571-1574
Sanghvi, N. T. ; Fry, F. J. ; Bihrle, Richard ; Foster, Richard ; Phillips, M. H. ; Syrus, J. ; Zaitsev, A. ; Hennige, C. / Microbubbles during tissue treatment using high intensity focused ultrasound. Proceedings of the IEEE Ultrasonics Symposium. Vol. 2 IEEE, 1995. pp. 1571-1574
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