Microbubbles during tissue treatment using high intensity focused ultrasound

N. T. Sanghvi, F. J. Fry, Richard Bihrle, Richard Foster, M. H. Phillips, J. Syrus, A. Zaitsev, C. Hennige

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations


Based on our previous animal experiments in the treatment of dog prostates and data from others, we selected HIFU parameters, (i.e. focal intensity, Isptp ≈ 1680 W/cm2, frequency = 4 MHz and treatment exposure time = 4 On / 12 Off sec.), to produce thermally induced focal lesions. Using the same acoustic parameters, patient treatment for the Benign Prostatic Hyperplasia (BPH) was commenced in 1992. During the treatment, in some patients, microbubble initiation at the focal site was observed. These microbubbles migrated towards the ultrasound near field as the HIFU procedure continued. To elucidate the similar response, animal experiments were carried out. This paper describes initiation of microbubbles at the focal site followed by their proliferation in the dog prostate during the treatment and finally their effects on tissue lesions. The microbubbles were observed by ultrasound imaging and monitored by subharmonics and broadband signals on the frequency spectrum analyzer. The temperature at the rectal wall was measured to observe and follow the effects of microbubbles in - vivo.

Original languageEnglish
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
Number of pages4
StatePublished - 1995
EventProceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2) - Seattle, WA, USA
Duration: Nov 7 1995Nov 10 1995


OtherProceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2)
CitySeattle, WA, USA


ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sanghvi, N. T., Fry, F. J., Bihrle, R., Foster, R., Phillips, M. H., Syrus, J., Zaitsev, A., & Hennige, C. (1995). Microbubbles during tissue treatment using high intensity focused ultrasound. In Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1571-1574). IEEE.