Microcirculation: Nexus of comorbidities in diabetes

Constance Temm, Jesus Dominguez

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Generalized capillary dysfunction is a morbid element in the metabolic syndrome, and it is likely involved in its complications. We tested the hypothesis that vast amounts of serum albumin previously observed in kidneys of rats with the metabolic syndrome were caused, in part, by leakage from renal peritubular capillaries. We report herein large scale leaks of plasma fluid in peritubular capillaries of rats with the metabolic syndrome. This finding was directly demonstrated in vivo, and the presence of leftover albumin residue confirmed the leak in postmortem kidney specimens. Moreover, renal interstitial fibrosis and tubular atrophy were found in a distribution similar to the leaked renal albumin in obese rats. We suggest that there is an important link between peritubular capillary damage and interstitial fibrosis, represented as tubulointerstitial disease in the metabolic syndrome. We propose that maintenance of the peritubular microcirculation may improve renal outcomes in diabetes and the metabolic syndrome.

Original languageEnglish
JournalAmerican Journal of Physiology - Renal Physiology
Volume293
Issue number2
DOIs
StatePublished - Aug 2007

Fingerprint

Microcirculation
Comorbidity
Kidney
Albumins
Fibrosis
Metabolic Diseases
Serum Albumin
Atrophy
Nexus
Maintenance

Keywords

  • Capillary permeability
  • Diabetic nephropathies

ASJC Scopus subject areas

  • Physiology

Cite this

Microcirculation : Nexus of comorbidities in diabetes. / Temm, Constance; Dominguez, Jesus.

In: American Journal of Physiology - Renal Physiology, Vol. 293, No. 2, 08.2007.

Research output: Contribution to journalArticle

@article{f26676787c124132a92373089cd34636,
title = "Microcirculation: Nexus of comorbidities in diabetes",
abstract = "Generalized capillary dysfunction is a morbid element in the metabolic syndrome, and it is likely involved in its complications. We tested the hypothesis that vast amounts of serum albumin previously observed in kidneys of rats with the metabolic syndrome were caused, in part, by leakage from renal peritubular capillaries. We report herein large scale leaks of plasma fluid in peritubular capillaries of rats with the metabolic syndrome. This finding was directly demonstrated in vivo, and the presence of leftover albumin residue confirmed the leak in postmortem kidney specimens. Moreover, renal interstitial fibrosis and tubular atrophy were found in a distribution similar to the leaked renal albumin in obese rats. We suggest that there is an important link between peritubular capillary damage and interstitial fibrosis, represented as tubulointerstitial disease in the metabolic syndrome. We propose that maintenance of the peritubular microcirculation may improve renal outcomes in diabetes and the metabolic syndrome.",
keywords = "Capillary permeability, Diabetic nephropathies",
author = "Constance Temm and Jesus Dominguez",
year = "2007",
month = "8",
doi = "10.1152/ajprenal.00503.2006",
language = "English",
volume = "293",
journal = "American Journal of Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Microcirculation

T2 - Nexus of comorbidities in diabetes

AU - Temm, Constance

AU - Dominguez, Jesus

PY - 2007/8

Y1 - 2007/8

N2 - Generalized capillary dysfunction is a morbid element in the metabolic syndrome, and it is likely involved in its complications. We tested the hypothesis that vast amounts of serum albumin previously observed in kidneys of rats with the metabolic syndrome were caused, in part, by leakage from renal peritubular capillaries. We report herein large scale leaks of plasma fluid in peritubular capillaries of rats with the metabolic syndrome. This finding was directly demonstrated in vivo, and the presence of leftover albumin residue confirmed the leak in postmortem kidney specimens. Moreover, renal interstitial fibrosis and tubular atrophy were found in a distribution similar to the leaked renal albumin in obese rats. We suggest that there is an important link between peritubular capillary damage and interstitial fibrosis, represented as tubulointerstitial disease in the metabolic syndrome. We propose that maintenance of the peritubular microcirculation may improve renal outcomes in diabetes and the metabolic syndrome.

AB - Generalized capillary dysfunction is a morbid element in the metabolic syndrome, and it is likely involved in its complications. We tested the hypothesis that vast amounts of serum albumin previously observed in kidneys of rats with the metabolic syndrome were caused, in part, by leakage from renal peritubular capillaries. We report herein large scale leaks of plasma fluid in peritubular capillaries of rats with the metabolic syndrome. This finding was directly demonstrated in vivo, and the presence of leftover albumin residue confirmed the leak in postmortem kidney specimens. Moreover, renal interstitial fibrosis and tubular atrophy were found in a distribution similar to the leaked renal albumin in obese rats. We suggest that there is an important link between peritubular capillary damage and interstitial fibrosis, represented as tubulointerstitial disease in the metabolic syndrome. We propose that maintenance of the peritubular microcirculation may improve renal outcomes in diabetes and the metabolic syndrome.

KW - Capillary permeability

KW - Diabetic nephropathies

UR - http://www.scopus.com/inward/record.url?scp=34548395147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548395147&partnerID=8YFLogxK

U2 - 10.1152/ajprenal.00503.2006

DO - 10.1152/ajprenal.00503.2006

M3 - Article

C2 - 17494088

AN - SCOPUS:34548395147

VL - 293

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0193-1857

IS - 2

ER -