Microcracks in articular calcified cartilage of human femoral heads

S. Mori, R. Harruff, David Burr

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The purpose of this work was to determine whether microcracks occur in calcified cartilage in vivo, and to use histological techniques to separate these from artifacts caused by processing. Six femoral heads without disease were split in the frontal plane. Sections from one slab were cut to 150 μm and stained with basic fuchsin. The other slab was stained en bloc, and sections were cut to 150 μm after staining. Sections were examined microscopically, and microcrack density was calculated. Data show that microcracks occur routinely in calcified cartilage from nondiseased femoral heads of aged humans, and that they can be separated from processing artifact. Their physiological significance is unknown, but it is possible that microcracks may trigger vascular invasion of subchondral bone and may play a role in the initiation and progression of osteoarthrosis.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume117
Issue number2
StatePublished - 1993

Fingerprint

Articular Cartilage
Thigh
Artifacts
Cartilage
Histological Techniques
Osteoarthritis
Blood Vessels
Staining and Labeling
Bone and Bones
basic fuchsin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Microcracks in articular calcified cartilage of human femoral heads. / Mori, S.; Harruff, R.; Burr, David.

In: Archives of Pathology and Laboratory Medicine, Vol. 117, No. 2, 1993, p. 196-198.

Research output: Contribution to journalArticle

Mori, S. ; Harruff, R. ; Burr, David. / Microcracks in articular calcified cartilage of human femoral heads. In: Archives of Pathology and Laboratory Medicine. 1993 ; Vol. 117, No. 2. pp. 196-198.
@article{094afac06c064d4cbb8e2ff07e3e9acc,
title = "Microcracks in articular calcified cartilage of human femoral heads",
abstract = "The purpose of this work was to determine whether microcracks occur in calcified cartilage in vivo, and to use histological techniques to separate these from artifacts caused by processing. Six femoral heads without disease were split in the frontal plane. Sections from one slab were cut to 150 μm and stained with basic fuchsin. The other slab was stained en bloc, and sections were cut to 150 μm after staining. Sections were examined microscopically, and microcrack density was calculated. Data show that microcracks occur routinely in calcified cartilage from nondiseased femoral heads of aged humans, and that they can be separated from processing artifact. Their physiological significance is unknown, but it is possible that microcracks may trigger vascular invasion of subchondral bone and may play a role in the initiation and progression of osteoarthrosis.",
author = "S. Mori and R. Harruff and David Burr",
year = "1993",
language = "English",
volume = "117",
pages = "196--198",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "2",

}

TY - JOUR

T1 - Microcracks in articular calcified cartilage of human femoral heads

AU - Mori, S.

AU - Harruff, R.

AU - Burr, David

PY - 1993

Y1 - 1993

N2 - The purpose of this work was to determine whether microcracks occur in calcified cartilage in vivo, and to use histological techniques to separate these from artifacts caused by processing. Six femoral heads without disease were split in the frontal plane. Sections from one slab were cut to 150 μm and stained with basic fuchsin. The other slab was stained en bloc, and sections were cut to 150 μm after staining. Sections were examined microscopically, and microcrack density was calculated. Data show that microcracks occur routinely in calcified cartilage from nondiseased femoral heads of aged humans, and that they can be separated from processing artifact. Their physiological significance is unknown, but it is possible that microcracks may trigger vascular invasion of subchondral bone and may play a role in the initiation and progression of osteoarthrosis.

AB - The purpose of this work was to determine whether microcracks occur in calcified cartilage in vivo, and to use histological techniques to separate these from artifacts caused by processing. Six femoral heads without disease were split in the frontal plane. Sections from one slab were cut to 150 μm and stained with basic fuchsin. The other slab was stained en bloc, and sections were cut to 150 μm after staining. Sections were examined microscopically, and microcrack density was calculated. Data show that microcracks occur routinely in calcified cartilage from nondiseased femoral heads of aged humans, and that they can be separated from processing artifact. Their physiological significance is unknown, but it is possible that microcracks may trigger vascular invasion of subchondral bone and may play a role in the initiation and progression of osteoarthrosis.

UR - http://www.scopus.com/inward/record.url?scp=0027463842&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027463842&partnerID=8YFLogxK

M3 - Article

VL - 117

SP - 196

EP - 198

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 2

ER -