Microfocal prostate cancer: Biopsy cancer volume does not predict actual tumour volume

Thomas Gardner, M. L. Lemer, P. N. Schlegel, R. S. Waldbaum, E. Darracott Vaughan, J. Steckel

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To determine whether microfocal prostate cancer on needle biopsy predicts clinically insignificant disease in men undergoing radical prostatectomy. Patients and methods: The records of 726 men who underwent radical prostatectomy between January 1990 and September 1995 were reviewed; 83 men had pre-operative prostatic needle biopsies which revealed microfocal prostate cancer. In these men, tumour volume (length) in the biopsy was compared to the percentage of tumour in the total prostatectomy specimen, and the pathological stage and clinical outcome reviewed. Results Of the 83 men with microfocal prostate cancer on biopsy 75 (90%) had clinically significant disease. Pre-operative variables were of no use in identifying patients with clinically insignificant tumour volumes. When comparing those with microfocal tumour and those without at one institution, 69% had organconfined (pT2) disease and 31% had capsular penetration (pT3), compared with 61% and 39%, respectively (P <0.05). Additionally, the positive surgical margin rate for those with microfocal tumour was only 6%, compared with 26% for those without microfocal disease (P

Original languageEnglish (US)
Pages (from-to)839-843
Number of pages5
JournalBritish Journal of Urology
Volume81
Issue number6
DOIs
StatePublished - 1998
Externally publishedYes

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Tumor Burden
Prostatic Neoplasms
Biopsy
Prostatectomy
Needle Biopsy
Neoplasms

Keywords

  • Biopsy
  • Microfocal cancer
  • Prostatectomy
  • Prostatic neoplasm

ASJC Scopus subject areas

  • Urology

Cite this

Gardner, T., Lemer, M. L., Schlegel, P. N., Waldbaum, R. S., Darracott Vaughan, E., & Steckel, J. (1998). Microfocal prostate cancer: Biopsy cancer volume does not predict actual tumour volume. British Journal of Urology, 81(6), 839-843. https://doi.org/10.1046/j.1464-410X.1998.00661.x

Microfocal prostate cancer : Biopsy cancer volume does not predict actual tumour volume. / Gardner, Thomas; Lemer, M. L.; Schlegel, P. N.; Waldbaum, R. S.; Darracott Vaughan, E.; Steckel, J.

In: British Journal of Urology, Vol. 81, No. 6, 1998, p. 839-843.

Research output: Contribution to journalArticle

Gardner, T, Lemer, ML, Schlegel, PN, Waldbaum, RS, Darracott Vaughan, E & Steckel, J 1998, 'Microfocal prostate cancer: Biopsy cancer volume does not predict actual tumour volume', British Journal of Urology, vol. 81, no. 6, pp. 839-843. https://doi.org/10.1046/j.1464-410X.1998.00661.x
Gardner, Thomas ; Lemer, M. L. ; Schlegel, P. N. ; Waldbaum, R. S. ; Darracott Vaughan, E. ; Steckel, J. / Microfocal prostate cancer : Biopsy cancer volume does not predict actual tumour volume. In: British Journal of Urology. 1998 ; Vol. 81, No. 6. pp. 839-843.
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