Abstract
We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF‐1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF‐1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF‐1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-33 |
| Number of pages | 9 |
| Journal | Glia |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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Keywords
- CSF‐1
- Limiting dilution analysis
- Trophic factor
ASJC Scopus subject areas
- Neurology
- Cellular and Molecular Neuroscience
Cite this
Microglia progenitor cells : A subpopulation in cultures of mouse neopallial astroglia. / Richardson, A.; Hao, Chunhai; Fedoroff, S.
In: Glia, Vol. 7, No. 1, 01.01.1993, p. 25-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microglia progenitor cells
T2 - A subpopulation in cultures of mouse neopallial astroglia
AU - Richardson, A.
AU - Hao, Chunhai
AU - Fedoroff, S.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF‐1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF‐1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF‐1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.
AB - We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF‐1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF‐1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF‐1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.
KW - CSF‐1
KW - Limiting dilution analysis
KW - Trophic factor
UR - http://www.scopus.com/inward/record.url?scp=0027351432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027351432&partnerID=8YFLogxK
U2 - 10.1002/glia.440070107
DO - 10.1002/glia.440070107
M3 - Article
VL - 7
SP - 25
EP - 33
JO - GLIA
JF - GLIA
SN - 0894-1491
IS - 1
ER -