Microglia progenitor cells: A subpopulation in cultures of mouse neopallial astroglia

A. Richardson, Chunhai Hao, S. Fedoroff

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF‐1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF‐1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF‐1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalGlia
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Microglia
Astrocytes
Stem Cells
Intercellular Signaling Peptides and Proteins
Neocortex
Fibroblasts
Bone Marrow
Macrophages

Keywords

  • CSF‐1
  • Limiting dilution analysis
  • Trophic factor

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Microglia progenitor cells : A subpopulation in cultures of mouse neopallial astroglia. / Richardson, A.; Hao, Chunhai; Fedoroff, S.

In: Glia, Vol. 7, No. 1, 01.01.1993, p. 25-33.

Research output: Contribution to journalArticle

Richardson, A. ; Hao, Chunhai ; Fedoroff, S. / Microglia progenitor cells : A subpopulation in cultures of mouse neopallial astroglia. In: Glia. 1993 ; Vol. 7, No. 1. pp. 25-33.
@article{257a147752cd46a483d87f01a0917e65,
title = "Microglia progenitor cells: A subpopulation in cultures of mouse neopallial astroglia",
abstract = "We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF‐1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF‐1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF‐1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.",
keywords = "CSF‐1, Limiting dilution analysis, Trophic factor",
author = "A. Richardson and Chunhai Hao and S. Fedoroff",
year = "1993",
month = "1",
day = "1",
doi = "10.1002/glia.440070107",
language = "English (US)",
volume = "7",
pages = "25--33",
journal = "GLIA",
issn = "0894-1491",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Microglia progenitor cells

T2 - A subpopulation in cultures of mouse neopallial astroglia

AU - Richardson, A.

AU - Hao, Chunhai

AU - Fedoroff, S.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF‐1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF‐1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF‐1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.

AB - We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF‐1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF‐1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF‐1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.

KW - CSF‐1

KW - Limiting dilution analysis

KW - Trophic factor

UR - http://www.scopus.com/inward/record.url?scp=0027351432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027351432&partnerID=8YFLogxK

U2 - 10.1002/glia.440070107

DO - 10.1002/glia.440070107

M3 - Article

C2 - 8423059

AN - SCOPUS:0027351432

VL - 7

SP - 25

EP - 33

JO - GLIA

JF - GLIA

SN - 0894-1491

IS - 1

ER -