Micronutrient deficiency independently predicts time to event in patients with heart failure

Terry A. Lennie, Christina Andreae, Mary Kay Rayens, Eun Kyeung Song, Sandra B. Dunbar, Susan Pressler, Seongkum Heo, Jin Shil Kim, Debra K. Moser

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background—Dietary micronutrient deficiencies have been shown to predict event-free survival in other countries but have not been examined in patients with heart failure living in the United States. The purpose of this study was to determine whether number of dietary micronutrient deficiencies in patients with heart failure was associated with shorter event-free survival, defined as a combined end point of all-cause hospitalization and death. Methods and Results—Four-day food diaries were collected from 246 patients with heart failure (age: 61.5_12 years; 67% male; 73% white; 45% New York Heart Association [NYHA] class III/IV) and analyzed using Nutrition Data Systems for Research. Micronutrient deficiencies were determined according to methods recommended by the Institute of Medicine. Patients were followed for 1 year to collect data on all-cause hospitalization or death. Patients were divided according to number of dietary micronutrient deficiencies at a cut point of ≥7 for the high deficiency category versus <7 for the no tomoderate deficiency category. In the full sample, 29.8% of patients experienced hospitalization or death during the year, including 44.3% in the high-deficiency group and 25.1% in the no/moderate group. The difference in survival distribution was significant (log rank, P=0.0065). In a Cox regression, micronutrient deficiency category predicted time to event with depression, NYHA classification, comorbidity burden, body mass index, calorie and sodium intake, and prescribed angiotensin-converting enzyme inhibitors, diuretics, or b-blockers included as covariates. Conclusions—This study provides additional convincing evidence that diet quality of patients with heart failure plays an important role in heart failure outcomes.

Original languageEnglish (US)
Article numbere007251
JournalJournal of the American Heart Association
Volume7
Issue number17
DOIs
StatePublished - Sep 1 2018

Fingerprint

Micronutrients
Heart Failure
Hospitalization
Disease-Free Survival
Diet Records
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Angiotensin-Converting Enzyme Inhibitors
Diuretics
Information Systems
Comorbidity
Cause of Death
Body Mass Index
Sodium
Diet
Survival
Research

Keywords

  • Diet
  • Heart failure
  • Nutrition
  • Risk factor
  • Survival analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Micronutrient deficiency independently predicts time to event in patients with heart failure. / Lennie, Terry A.; Andreae, Christina; Rayens, Mary Kay; Song, Eun Kyeung; Dunbar, Sandra B.; Pressler, Susan; Heo, Seongkum; Kim, Jin Shil; Moser, Debra K.

In: Journal of the American Heart Association, Vol. 7, No. 17, e007251, 01.09.2018.

Research output: Contribution to journalArticle

Lennie, Terry A. ; Andreae, Christina ; Rayens, Mary Kay ; Song, Eun Kyeung ; Dunbar, Sandra B. ; Pressler, Susan ; Heo, Seongkum ; Kim, Jin Shil ; Moser, Debra K. / Micronutrient deficiency independently predicts time to event in patients with heart failure. In: Journal of the American Heart Association. 2018 ; Vol. 7, No. 17.
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