MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance

Elizabeth C. Martin, Adrienne K. Conger, Thomas J. Yan, Van T. Hoang, David F B Miller, Aaron Buechlein, Douglas B. Rusch, Kenneth Nephew, Bridgette M. Collins-Burow, Matthew E. Burow

Research output: Contribution to journalLetter

13 Citations (Scopus)

Abstract

microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and play critical roles in human malignancies. Next-generation sequencing analysis of the MCF-7 breast cancer cell line overexpressing miR-335-5p and miR-335-3p demonstrated that the miRNA duplex repressed genes involved in the ERα signaling pathway, and enhanced resistance of MCF-7 cells to the growth inhibitory effects of tamoxifen. These data suggest that despite its conventional role in tumor suppression, the miR-335 transcript can also play an oncogenic role in promoting agonistic estrogen signaling in a cancerous setting.

Original languageEnglish (US)
Pages (from-to)382-392
Number of pages11
JournalFEBS Letters
Volume591
Issue number2
DOIs
StatePublished - Jan 1 2017

Fingerprint

Estrogen Receptor alpha
Tamoxifen
MicroRNAs
Small Untranslated RNA
MCF-7 Cells
Gene Expression Regulation
Gene expression
Tumors
Neoplasms
Estrogens
Genes
Cells
Breast Neoplasms
Cell Line
Molecules
Growth

Keywords

  • breast cancer
  • endocrine resistance
  • estrogen receptor
  • isoform
  • microRNA
  • miRNA-335

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Martin, E. C., Conger, A. K., Yan, T. J., Hoang, V. T., Miller, D. F. B., Buechlein, A., ... Burow, M. E. (2017). MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance. FEBS Letters, 591(2), 382-392. https://doi.org/10.1002/1873-3468.12538

MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance. / Martin, Elizabeth C.; Conger, Adrienne K.; Yan, Thomas J.; Hoang, Van T.; Miller, David F B; Buechlein, Aaron; Rusch, Douglas B.; Nephew, Kenneth; Collins-Burow, Bridgette M.; Burow, Matthew E.

In: FEBS Letters, Vol. 591, No. 2, 01.01.2017, p. 382-392.

Research output: Contribution to journalLetter

Martin, EC, Conger, AK, Yan, TJ, Hoang, VT, Miller, DFB, Buechlein, A, Rusch, DB, Nephew, K, Collins-Burow, BM & Burow, ME 2017, 'MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance', FEBS Letters, vol. 591, no. 2, pp. 382-392. https://doi.org/10.1002/1873-3468.12538
Martin, Elizabeth C. ; Conger, Adrienne K. ; Yan, Thomas J. ; Hoang, Van T. ; Miller, David F B ; Buechlein, Aaron ; Rusch, Douglas B. ; Nephew, Kenneth ; Collins-Burow, Bridgette M. ; Burow, Matthew E. / MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance. In: FEBS Letters. 2017 ; Vol. 591, No. 2. pp. 382-392.
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