MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects

Justin M. Long, Balmiki Ray, Debomoy K. Lahiri

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Background: BACE1 is the rate-limiting enzyme in the synthesis of Aβ from amyloid precursor protein. Results: Human miR-339-5p negatively regulates BACE1 and Aβ in human brain cultures and is reduced in AD specimens. Conclusion: Human miR-339-5p physiologically regulates human BACE1 protein expression and Aβ and is dysregulated in the AD brain. Significance: miR-339-5p represents a novel drug target in AD.

Original languageEnglish (US)
Pages (from-to)5184-5198
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
StatePublished - Feb 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects'. Together they form a unique fingerprint.

  • Cite this