MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease

Hyejin Yoon, Luis F. Flores, Jungsu Kim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Cholesterol is important for various neuronal functions in the brain. Brain has elaborate regulatory mechanisms to control cholesterol metabolism that are distinct from the mechanisms in periphery. Interestingly, dysregulation of the cholesterol metabolism is strongly associated with a number of neurodegenerative diseases. MicroRNAs are short non-coding RNAs acting as post-transcriptional gene regulators. Recently, several microRNAs are demonstrated to be involved in regulating cholesterol metabolism in the brain. This article reviews the regulatory mechanisms of cellular cholesterol homeostasis in the brain. In addition, we discuss the role of microRNAs in brain cholesterol metabolism and their potential implications for the treatment of Alzheimer's disease. This article is part of a special issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.

Original languageEnglish (US)
Pages (from-to)2139-2147
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1861
Issue number12
DOIs
StatePublished - Dec 1 2016

Keywords

  • Alzheimer's disease
  • Central nervous system
  • Cholesterol metabolism
  • Lipid metabolism
  • MicroRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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