Microscopic eosinophilic esophagitis in children correlates with endoscopie vertical Unes in the esophageal mucosa (VLEM)

M. H. Collins, S. K. Gupta, J. F. Fitzgerald, S. K.F. Chong, J. M. Croffie

Research output: Contribution to journalArticle

Abstract

VLEM are an endoscopie abnormality of symptomatic children with symptoms of gastroesophageal reflux disease. VLEM were found in 41 endoscopie procedures performed on 22 males and 8 females from 1 to 18.4 years of age (mean 8.3 years) and were not found in 76 males and 78 females 0.17 to 17.3 years of age (mean 5.62 years). The proportion of males and the mean age of the patients were significantly greater in the VLEM group. Only 1 of 41 biopsies from the VLEM group was read as normal, compared to 92 of 160 biopsies from the group without VLEM; the inflammation in 34 VLEM biopsies was subjectivelyjudged to be moderate to severe compared to 14 biopsies without VLEM (Gastrointest Endosc 4338, 1995, abstr). To quantify the difference between the groups, eosinophils and neutrophils were counted in 20 VLEM biopsies and 22 without VLEM. There was a mean of 0.84 neutrophils/mm2 in no-VLEM biopsies compared to 2.29/mm2 in VLF.M biopsies. There were 4.37 eosinophils/mm2 in noVLEM biopsies compared to 18.4/mm2 in VLEM biopsies (P < .5). VLEM correlates strongly with eosinophilic esophageal inflammation in children.

Original languageEnglish (US)
Pages (from-to)352-353
Number of pages2
JournalPediatric Pathology and Laboratory Medicine
Volume16
Issue number2
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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