Microtubule-associated proteins tau and amyloid P component in Alzheimer's disease

Taihung Duong, Therese Doucette, Nichole A. Zidenberg, Roland W. Jacobs, Arnold B. Scheibel

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The localization of the intracerebral microtubule-associated proteins tau (MAP-tau) has been compared to that of amyloid P component (AP), an extracerebral protein, by single- and double-antigen immunohistochemistry in neurofibrillary tangles of Alzheimer's brains. The resulsts show that, individually, MAP-tau and AP may be observed in all stages of neurofibrillary tangle (NFT) formation. However, NFT labeled by MAP-tau and those labeled by AP largely do not overlap in their distribution. Furthermore, within the few NFT double-labeled by MAP-tau and AP, there was an inverse relationship between the immunoreactivity to MAP-tau and to AP. It is suggested that MAP-tau and AP are incorporated at different times into NFT and that this difference in the timing of NFT expression of these 2 proteins may be useful in the study of progressive NFT formation.

Original languageEnglish (US)
Pages (from-to)74-86
Number of pages13
JournalBrain research
Volume603
Issue number1
DOIs
StatePublished - Feb 12 1993

Keywords

  • Dorsal raphé nucleus
  • Double-antigen immunohistochemistry
  • Entorhinal cortex
  • Hippocampus
  • Locus coeruleus
  • Neurofibrillary tangle
  • Paired helical filament

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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