Microtubule-associated proteins tau and amyloid P component in Alzheimer's disease

Taihung Duong, Therese Doucette, Nichole A. Zidenberg, Roland W. Jacobs, Arnold B. Scheibel

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The localization of the intracerebral microtubule-associated proteins tau (MAP-tau) has been compared to that of amyloid P component (AP), an extracerebral protein, by single- and double-antigen immunohistochemistry in neurofibrillary tangles of Alzheimer's brains. The resulsts show that, individually, MAP-tau and AP may be observed in all stages of neurofibrillary tangle (NFT) formation. However, NFT labeled by MAP-tau and those labeled by AP largely do not overlap in their distribution. Furthermore, within the few NFT double-labeled by MAP-tau and AP, there was an inverse relationship between the immunoreactivity to MAP-tau and to AP. It is suggested that MAP-tau and AP are incorporated at different times into NFT and that this difference in the timing of NFT expression of these 2 proteins may be useful in the study of progressive NFT formation.

Original languageEnglish (US)
Pages (from-to)74-86
Number of pages13
JournalBrain research
Volume603
Issue number1
DOIs
StatePublished - Feb 12 1993

Fingerprint

Serum Amyloid P-Component
Neurofibrillary Tangles
Microtubule-Associated Proteins
Alzheimer Disease
Proteins
Immunohistochemistry
Antigens
Brain

Keywords

  • Dorsal raphé nucleus
  • Double-antigen immunohistochemistry
  • Entorhinal cortex
  • Hippocampus
  • Locus coeruleus
  • Neurofibrillary tangle
  • Paired helical filament

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Microtubule-associated proteins tau and amyloid P component in Alzheimer's disease. / Duong, Taihung; Doucette, Therese; Zidenberg, Nichole A.; Jacobs, Roland W.; Scheibel, Arnold B.

In: Brain research, Vol. 603, No. 1, 12.02.1993, p. 74-86.

Research output: Contribution to journalArticle

Duong, Taihung ; Doucette, Therese ; Zidenberg, Nichole A. ; Jacobs, Roland W. ; Scheibel, Arnold B. / Microtubule-associated proteins tau and amyloid P component in Alzheimer's disease. In: Brain research. 1993 ; Vol. 603, No. 1. pp. 74-86.
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