Microtubule-based motor function in mitosis

Rebecca Heald, Claire E. Walczak

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Microtubule-based motors are essential both for the proper assembly of the mitotic spindle and for chromosome segregation. Mitotic motors in the yeast Saccharomyces cerevisiae exhibit either overlapping or opposing activities in order to achieve proper spindle function, whereas the analysis of motors using vertebrate cytoplasmic extracts has revealed less functional redundancy. In several systems, biochemical, genetic and two-hybrid approaches have been used both to identify associated nonmotor proteins and to address the molecular mechanisms behind kinetochore movements during chromosome alignment and segregation.

Original languageEnglish (US)
Pages (from-to)268-274
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume9
Issue number2
DOIs
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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