Microtubule dynamics and tubulin interacting proteins

Research output: Contribution to journalReview article

136 Scopus citations


Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Microtubule dynamics and tubulin interacting proteins'. Together they form a unique fingerprint.

  • Cite this