Microtubule dynamics and tubulin interacting proteins

Research output: Contribution to journalReview article

136 Scopus citations

Abstract

Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalCurrent Opinion in Cell Biology
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Cell Biology

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