Microtubule dynamics and tubulin interacting proteins

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalCurrent Opinion in Cell Biology
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2000

Fingerprint

Tubulin
Microtubules
Proteins
Stathmin
Spindle Apparatus
Interphase
Cell Extracts
Mitosis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Microtubule dynamics and tubulin interacting proteins. / Walczak, Claire.

In: Current Opinion in Cell Biology, Vol. 12, No. 1, 01.02.2000, p. 52-56.

Research output: Contribution to journalArticle

@article{f93a5fcbb98b4756afcece72c2660c31,
title = "Microtubule dynamics and tubulin interacting proteins",
abstract = "Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.",
author = "Claire Walczak",
year = "2000",
month = "2",
day = "1",
doi = "10.1016/S0955-0674(99)00056-3",
language = "English",
volume = "12",
pages = "52--56",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Microtubule dynamics and tubulin interacting proteins

AU - Walczak, Claire

PY - 2000/2/1

Y1 - 2000/2/1

N2 - Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.

AB - Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.

UR - http://www.scopus.com/inward/record.url?scp=0033965785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033965785&partnerID=8YFLogxK

U2 - 10.1016/S0955-0674(99)00056-3

DO - 10.1016/S0955-0674(99)00056-3

M3 - Article

C2 - 10679354

AN - SCOPUS:0033965785

VL - 12

SP - 52

EP - 56

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 1

ER -