Microtubule dynamics in Xenopus egg extracts

Mimi Shirasu, Ann Yonetani, Claire E. Walczak

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The organization and function of microtubules change dramatically during the cell cycle. At the onset of mitosis, a radial array of microtubules is broken down and reorganized into a bipolar spindle. This event requires changes in the dynamic behavior of individual microtubules. Through the use of Xenopus laevis egg extracts, a number of proteins affecting microtubule behavior have been identified. Recently, progress has also been made towards understanding how the activities of such microtubule-affecting proteins are regulated in a cell cycle-dependent manner. It is hoped that understanding how microtubule behavior is controlled during the cell cycle in vitro may illuminate the role of microtubule dynamics in various cellular processes.

Original languageEnglish (US)
Pages (from-to)435-445
Number of pages11
JournalMicroscopy Research and Technique
Volume44
Issue number6
DOIs
StatePublished - Mar 15 1999

Keywords

  • Cell cycle
  • Cellular function
  • Microtubule
  • Proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

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