Microtubule dynamics in Xenopus egg extracts

Mimi Shirasu, Ann Yonetani, Claire Walczak

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The organization and function of microtubules change dramatically during the cell cycle. At the onset of mitosis, a radial array of microtubules is broken down and reorganized into a bipolar spindle. This event requires changes in the dynamic behavior of individual microtubules. Through the use of Xenopus laevis egg extracts, a number of proteins affecting microtubule behavior have been identified. Recently, progress has also been made towards understanding how the activities of such microtubule-affecting proteins are regulated in a cell cycle-dependent manner. It is hoped that understanding how microtubule behavior is controlled during the cell cycle in vitro may illuminate the role of microtubule dynamics in various cellular processes.

Original languageEnglish
Pages (from-to)435-445
Number of pages11
JournalMicroscopy Research and Technique
Volume44
Issue number6
DOIs
StatePublished - Mar 15 1999

Fingerprint

eggs
Xenopus
Microtubules
microtubules
Ovum
Cells
cycles
extracts
Microtubule Proteins
Cell Cycle
proteins
Proteins
mitosis
spindles
cell cycle
Xenopus laevis
Mitosis

Keywords

  • Cell cycle
  • Cellular function
  • Microtubule
  • Proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Microtubule dynamics in Xenopus egg extracts. / Shirasu, Mimi; Yonetani, Ann; Walczak, Claire.

In: Microscopy Research and Technique, Vol. 44, No. 6, 15.03.1999, p. 435-445.

Research output: Contribution to journalArticle

Shirasu, Mimi ; Yonetani, Ann ; Walczak, Claire. / Microtubule dynamics in Xenopus egg extracts. In: Microscopy Research and Technique. 1999 ; Vol. 44, No. 6. pp. 435-445.
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