Microvascular control in intestinal mucosa of normal and hemorrhaged rats

H. Bohlen, P. M. Hutchins, C. E. Rapela, H. D. Green

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)

Abstract

The mucosal microcirculation in innervated and denervated small intestine was studied using anesthetized rats. Denervation did not cause significant (P > 0.05) diameter changes in the precapillary vasculature; however, venules did constrict significantly. These results indicate minimum neural control in the precapillary vasculature during the resting state. The innervated precapillary vasculature constricted during both the carotid occlusion reflex and hemorrhagic hypotension. The diameter of the denervated precapillary vasculature was unchanged during the carotid occlusion reflex and dilated during hemorrhage. The responses of innervated and denervated precapillary vasculatures were attributed to increased neural activity and autoregulatory mechanisms, respectively. Neither innervated nor denervated venules responded during the carotid occlusion reflex. During hemorrhage, however, innervated venules constricted and denervated vessels dilated. The vasoconstriction of the innervated vasculature during hemorrhage contributed to a stoppage of blood and epithelial detachment; these responses did not occur in the dilated, denervated vasculature. Therefore, neural vasoconstriction, qualitatively similar to that in normal animals during the baroreceptor reflex, is a contributing cause to the vascular and tissue impairment in the intestinal mucosa during hemorrhage.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology
Pages1159-1164
Number of pages6
Volume229
Edition5
StatePublished - 1975
Externally publishedYes

Fingerprint

Intestinal Mucosa
Venules
Hemorrhage
Reflex
Vasoconstriction
Baroreflex
Denervation
Microcirculation
Hypotension
Small Intestine
Blood Vessels

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bohlen, H., Hutchins, P. M., Rapela, C. E., & Green, H. D. (1975). Microvascular control in intestinal mucosa of normal and hemorrhaged rats. In American Journal of Physiology (5 ed., Vol. 229, pp. 1159-1164)

Microvascular control in intestinal mucosa of normal and hemorrhaged rats. / Bohlen, H.; Hutchins, P. M.; Rapela, C. E.; Green, H. D.

American Journal of Physiology. Vol. 229 5. ed. 1975. p. 1159-1164.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bohlen, H, Hutchins, PM, Rapela, CE & Green, HD 1975, Microvascular control in intestinal mucosa of normal and hemorrhaged rats. in American Journal of Physiology. 5 edn, vol. 229, pp. 1159-1164.
Bohlen H, Hutchins PM, Rapela CE, Green HD. Microvascular control in intestinal mucosa of normal and hemorrhaged rats. In American Journal of Physiology. 5 ed. Vol. 229. 1975. p. 1159-1164
Bohlen, H. ; Hutchins, P. M. ; Rapela, C. E. ; Green, H. D. / Microvascular control in intestinal mucosa of normal and hemorrhaged rats. American Journal of Physiology. Vol. 229 5. ed. 1975. pp. 1159-1164
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