Microvascular pressures in rat intestinal muscle during direct nerve stimulation

H. Bohlen, Robert W. Gore

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Microvascular pressures are assumed to be lowered by the vasoconstriction caused during increased activity of the sympathetic nervous system. This hypothesis was tested by direct simultaneous measurements of microvascular pressures and inner vessel diameters in rat intestinal muscle before and during sympathetic stimulation. Measurements of inner vessel diameter and pressure were made with a video micrometer and a servo-null pressure transducer, respectively. Direct sympathetic stimulation at 4, 8, and 16 Hz (5-7 V, 2-msec duration) was used to mimic increased sympathetic activity. Stimulation at 8 and 16 Hz caused a reduction in microvascular pressure and inner vessel diameters throughout the microcirculation. The primary site of pressure reduction was in the smallest arterioles during 8-Hz stimulation and in the largest arterioles during 16-Hz stimulation. These data are interpreted to indicate that the major site of microvascular pressure reduction shifted from the small to large arterioles as the frequency of sympathetic stimulation increased.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalMicrovascular Research
Volume17
Issue number1
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Muscle
Rats
Pressure
Muscles
Arterioles
Microcirculation
Pressure Transducers
Pressure transducers
Sympathetic Nervous System
Neurology
Vasoconstriction

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

Cite this

Microvascular pressures in rat intestinal muscle during direct nerve stimulation. / Bohlen, H.; Gore, Robert W.

In: Microvascular Research, Vol. 17, No. 1, 1979, p. 27-37.

Research output: Contribution to journalArticle

@article{6cb6a65d5884439d8946e2ae04a63a05,
title = "Microvascular pressures in rat intestinal muscle during direct nerve stimulation",
abstract = "Microvascular pressures are assumed to be lowered by the vasoconstriction caused during increased activity of the sympathetic nervous system. This hypothesis was tested by direct simultaneous measurements of microvascular pressures and inner vessel diameters in rat intestinal muscle before and during sympathetic stimulation. Measurements of inner vessel diameter and pressure were made with a video micrometer and a servo-null pressure transducer, respectively. Direct sympathetic stimulation at 4, 8, and 16 Hz (5-7 V, 2-msec duration) was used to mimic increased sympathetic activity. Stimulation at 8 and 16 Hz caused a reduction in microvascular pressure and inner vessel diameters throughout the microcirculation. The primary site of pressure reduction was in the smallest arterioles during 8-Hz stimulation and in the largest arterioles during 16-Hz stimulation. These data are interpreted to indicate that the major site of microvascular pressure reduction shifted from the small to large arterioles as the frequency of sympathetic stimulation increased.",
author = "H. Bohlen and Gore, {Robert W.}",
year = "1979",
doi = "10.1016/0026-2862(79)90005-0",
language = "English (US)",
volume = "17",
pages = "27--37",
journal = "Microvascular Research",
issn = "0026-2862",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Microvascular pressures in rat intestinal muscle during direct nerve stimulation

AU - Bohlen, H.

AU - Gore, Robert W.

PY - 1979

Y1 - 1979

N2 - Microvascular pressures are assumed to be lowered by the vasoconstriction caused during increased activity of the sympathetic nervous system. This hypothesis was tested by direct simultaneous measurements of microvascular pressures and inner vessel diameters in rat intestinal muscle before and during sympathetic stimulation. Measurements of inner vessel diameter and pressure were made with a video micrometer and a servo-null pressure transducer, respectively. Direct sympathetic stimulation at 4, 8, and 16 Hz (5-7 V, 2-msec duration) was used to mimic increased sympathetic activity. Stimulation at 8 and 16 Hz caused a reduction in microvascular pressure and inner vessel diameters throughout the microcirculation. The primary site of pressure reduction was in the smallest arterioles during 8-Hz stimulation and in the largest arterioles during 16-Hz stimulation. These data are interpreted to indicate that the major site of microvascular pressure reduction shifted from the small to large arterioles as the frequency of sympathetic stimulation increased.

AB - Microvascular pressures are assumed to be lowered by the vasoconstriction caused during increased activity of the sympathetic nervous system. This hypothesis was tested by direct simultaneous measurements of microvascular pressures and inner vessel diameters in rat intestinal muscle before and during sympathetic stimulation. Measurements of inner vessel diameter and pressure were made with a video micrometer and a servo-null pressure transducer, respectively. Direct sympathetic stimulation at 4, 8, and 16 Hz (5-7 V, 2-msec duration) was used to mimic increased sympathetic activity. Stimulation at 8 and 16 Hz caused a reduction in microvascular pressure and inner vessel diameters throughout the microcirculation. The primary site of pressure reduction was in the smallest arterioles during 8-Hz stimulation and in the largest arterioles during 16-Hz stimulation. These data are interpreted to indicate that the major site of microvascular pressure reduction shifted from the small to large arterioles as the frequency of sympathetic stimulation increased.

UR - http://www.scopus.com/inward/record.url?scp=0018408895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018408895&partnerID=8YFLogxK

U2 - 10.1016/0026-2862(79)90005-0

DO - 10.1016/0026-2862(79)90005-0

M3 - Article

VL - 17

SP - 27

EP - 37

JO - Microvascular Research

JF - Microvascular Research

SN - 0026-2862

IS - 1

ER -