Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons

Horacio Vanegas, Nicholas Barbaro, Howard L. Fields

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The effects of midbrain electrical stimulation on the activity of tail-flick (TF) related neurons in the rostral ventromedial medulla (RVM) were studied. Neurons whose activity either decreased (off-cells) or increased (on-cells) immediately prior to TF were examined. Of 31 off- and on-cells, 26 (84%) showed increased activity during midbrain stimulation sufficient to suppress the TF. Furthermore, in 21 of these cells, the threshold for activation was identical to the threshold for TF suppression, and in the other 5 cells the threshold difference was ≤5 μA. This study provides evidence that off- and on-cells in the RVM mediate the antinociceptive actions of midbrain stimulation.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalBrain Research
Volume321
Issue number1
DOIs
StatePublished - Oct 29 1984
Externally publishedYes

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Mesencephalon
Neurons
Electric Stimulation

Keywords

  • analgesia
  • nucleus raphe magnus
  • periaqueductal gray
  • rat
  • stimulation-produced analgesia
  • tail-flick test

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons. / Vanegas, Horacio; Barbaro, Nicholas; Fields, Howard L.

In: Brain Research, Vol. 321, No. 1, 29.10.1984, p. 127-133.

Research output: Contribution to journalArticle

Vanegas, Horacio ; Barbaro, Nicholas ; Fields, Howard L. / Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons. In: Brain Research. 1984 ; Vol. 321, No. 1. pp. 127-133.
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