Mild traumatic brain injury results in extensive neuronal degeneration in the cerebral cortex

Xiang Gao, Jinhui Chen

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Mild traumatic brain injury (mTBI) leads to long-term cognitive and emotional difficulties and behavioral disturbances, but the diagnosis and treatment of mTBI have historically been hampered by a lack of evidence-based correlates of these clinical manifestations. Unlike moderate and severe TBI, mTBI does not show significant tissue lesions or cavities in the cortex. Moreover, neuroimaging by magnetic resonance imaging or computed tomography is usually negative, suggesting that the damage is beyond the resolution of current structure-based scanning technologies. Therefore, we investigated the morphologies of spared neurons in the mouse cortex after mTBI in a controlled cortical impact injury model. Our results indicate that, although mTBI caused only a mild extent of cell death, it led to extensive dendrite degeneration and synapse reduction in the cortex in this model. This study sheds light on the neuropathologic consequences of mTBI in humans and suggests that neurodegeneration may be a novel target for developing diagnostic methods and therapeutic approaches for mTBI.

Original languageEnglish (US)
Pages (from-to)183-191
Number of pages9
JournalJournal of Neuropathology and Experimental Neurology
Volume70
Issue number3
DOIs
StatePublished - Mar 1 2011

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Keywords

  • Dendrite
  • mTBI
  • Neural degeneration
  • Spine
  • Synapse

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Neurology
  • Cellular and Molecular Neuroscience

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