Minimal-Change Nephrotic Syndrome Associated With Malignant Mesothelioma

Neal J. Schroeter, Daniel A. Rushing, John P. Parker, Efstahios Beltaos

Research output: Contribution to journalArticle

19 Scopus citations


• A 68-year-old man presented with nephrotic syndrome. Renal biopsy revealed minimal-change glomerular disease. The proteinuria did not respond to treatment with prednisone and cyclophosphamide. On further workup, the patient was found to have a malignant mesothelioma of the pleura. The proteinuria then improved during treatment with doxorubicin hydrochloride and dacarbazine, without noticeable improvement in the tumor. This case suggests an association between mesothelioma and minimal-change glomerular disease with nephrotic syndrome, previously unreported to our knowledge. Our review revealed only ten previous cases of minimalchange glomerular disease associated with carcinoma.

Original languageEnglish (US)
Pages (from-to)1834-1836
Number of pages3
JournalArchives of Internal Medicine
Issue number9
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Internal Medicine

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