Minireview: The roles of small RNA pathways in reproductive medicine

Shannon Hawkins, Gregory M. Buchold, Martin M. Matzuk

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

The discovery of small noncoding RNA, including P-element-induced wimpy testis-interacting RNA, small interfering RNA, and microRNA, has energized research in reproductive medicine. In the two decades since the identification of small RNA, first in Caenorhabditis elegans and then in other animals, scientists in many disciplines have made significant progress in elucidating their biology. A powerful battery of tools, including knockout mice and small RNA mimics and antagonists, has facilitated investigation into the functional roles and therapeutic potential of these small RNA pathways. Current data indicate that small RNA play significant roles in normal development and physiology and pathological conditions of the reproductive tracts of females and males. Biologically plausible mRNA targets for these microRNA are aggressively being discovered. The next phase of research will focus on elucidating the clinical utility of small RNA-selective agonists and antagonists.

Original languageEnglish (US)
Pages (from-to)1257-1279
Number of pages23
JournalMolecular Endocrinology
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Fingerprint

Reproductive Medicine
RNA
MicroRNAs
Small Untranslated RNA
Caenorhabditis elegans
Research
Knockout Mice
Small Interfering RNA
Testis
Messenger RNA

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

Minireview : The roles of small RNA pathways in reproductive medicine. / Hawkins, Shannon; Buchold, Gregory M.; Matzuk, Martin M.

In: Molecular Endocrinology, Vol. 25, No. 8, 01.08.2011, p. 1257-1279.

Research output: Contribution to journalReview article

Hawkins, Shannon ; Buchold, Gregory M. ; Matzuk, Martin M. / Minireview : The roles of small RNA pathways in reproductive medicine. In: Molecular Endocrinology. 2011 ; Vol. 25, No. 8. pp. 1257-1279.
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