MiR-210: Fine-tuning the hypoxic response

Mircea Ivan, Xin Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

50 Citations (Scopus)

Abstract

Hypoxia is a central component of the tumor microenvironment and represents a major source of therapeutic failure in cancer therapy. Recent work has provided a wealth of evidence that noncoding RNAs and, in particular, microRNAs, are significant members of the adaptive response to low oxygen in tumors. All published studies agree that miR-210 specifically is a robust target of hypoxia-inducible factors, and the induction of miR-210 is a consistent characteristic of the hypoxic response in normal and transformed cells. Overexpression of miR-210 is detected in most solid tumors and has been linked to adverse prognosis in patients with soft-tissue sarcoma, breast, head and neck, and pancreatic cancer. A wide variety of miR-210 targets have been identified, pointing to roles in the cell cycle, mitochondrial oxidative metabolism, angiogenesis, DNA damage response, and cell survival. Additional microRNAs seem to be modulated by low oxygen in a more tissue-specific fashion, adding another layer of complexity to the vast array of protein-coding genes regulated by hypoxia.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages205-227
Number of pages23
Volume772
ISBN (Print)9781461459149
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume772
ISSN (Print)00652598

Fingerprint

Tumors
Tuning
MicroRNAs
Cells
Tissue
Oxygen
Neoplasms
Protein Array Analysis
Untranslated RNA
Tumor Microenvironment
Head and Neck Neoplasms
Pancreatic Neoplasms
Metabolism
Sarcoma
DNA Damage
Cell Survival
Cell Cycle
Breast
Genes
DNA

Keywords

  • Apoptosis
  • Biomarker
  • Cancer
  • Hypoxia
  • Metabolism
  • microRNA
  • miR-210
  • Mitochondria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ivan, M., & Huang, X. (2014). MiR-210: Fine-tuning the hypoxic response. In Advances in Experimental Medicine and Biology (Vol. 772, pp. 205-227). (Advances in Experimental Medicine and Biology; Vol. 772). Springer New York LLC. https://doi.org/10.1007/978-1-4614-5915-6_10

MiR-210 : Fine-tuning the hypoxic response. / Ivan, Mircea; Huang, Xin.

Advances in Experimental Medicine and Biology. Vol. 772 Springer New York LLC, 2014. p. 205-227 (Advances in Experimental Medicine and Biology; Vol. 772).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ivan, M & Huang, X 2014, MiR-210: Fine-tuning the hypoxic response. in Advances in Experimental Medicine and Biology. vol. 772, Advances in Experimental Medicine and Biology, vol. 772, Springer New York LLC, pp. 205-227. https://doi.org/10.1007/978-1-4614-5915-6_10
Ivan M, Huang X. MiR-210: Fine-tuning the hypoxic response. In Advances in Experimental Medicine and Biology. Vol. 772. Springer New York LLC. 2014. p. 205-227. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-5915-6_10
Ivan, Mircea ; Huang, Xin. / MiR-210 : Fine-tuning the hypoxic response. Advances in Experimental Medicine and Biology. Vol. 772 Springer New York LLC, 2014. pp. 205-227 (Advances in Experimental Medicine and Biology).
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