Mirna expression in bladder cancer and their potential role in clinical practice

Ana Blanca, Liang Cheng, Rodolfo Montironi, Holger Moch, Francesco Massari, Michelangelo Fiorentino, Maria Rosaria Raspollini, Marina Scarpelli, Antonio Lopez-Beltran

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Background: To date more than 3000 miRNA sequences have been described in humans and registered at miRBase since their discovery. However, the functions of only a few of these miRNAs have been experimentally determined using deep sequencing technology. Aberrant miRNA expression has been associated with differentiation, invasion and metastasis in several cancers. In this context, recent reports have suggested that miRNAs play important roles in the regulation of target genes by binding to complementary regions of messenger transcripts to repress their translation or regulate degradation. In addition, the expression profiles of certain miRNAs can function biologically as oncogenes and tumor suppressor genes. Method: In this review, we summarize the relationship between miRNAs expression and Bladder Cancer (BC). A comprehensive review of the literature has shown a differential expression between malignant and normal tissues, and that miRNAs could be the driving molecules of the BC progression. Similarly, the expression levels of miRNAs in urine and blood samples of BC patients have been demonstrated to be different from healthy people, a finding that might have diagnostic value. Conclusion: In conclusion, the understanding of miRNAs mechanisms and cell distribution provides new opportunities for diagnosis, prognostic, disease monitoring and personalized therapy of BC patients.

Original languageEnglish (US)
Pages (from-to)712-722
Number of pages11
JournalCurrent Drug Metabolism
Volume18
Issue number8
DOIs
StatePublished - Jan 1 2017

Keywords

  • Biomarker
  • Bladder cancer
  • Diagnosis
  • Disease monitoring
  • MIRNA
  • Prognosis

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Mirna expression in bladder cancer and their potential role in clinical practice'. Together they form a unique fingerprint.

  • Cite this

    Blanca, A., Cheng, L., Montironi, R., Moch, H., Massari, F., Fiorentino, M., Raspollini, M. R., Scarpelli, M., & Lopez-Beltran, A. (2017). Mirna expression in bladder cancer and their potential role in clinical practice. Current Drug Metabolism, 18(8), 712-722. https://doi.org/10.2174/1389200218666170518164507