Missing motoric manipulations

rethinking the imaging of the ventral striatum and dopamine in human reward

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Human neuroimaging studies of natural rewards and drugs of abuse frequently assay the brain’s response to stimuli that, through Pavlovian learning, have come to be associated with a drug’s rewarding properties. This might be characterized as a ‘sensorial’ view of the brain’s reward system, insofar as the paradigms are designed to elicit responses to a reward’s (drug’s) sight, aroma, or flavor. A different field of research nevertheless suggests that the mesolimbic dopamine system may also be critically involved in the motor behaviors provoked by such stimuli. This brief review and commentary surveys some of the preclinical data supporting this more “efferent” (motoric) view of the brain’s reward system, and discusses what such findings might mean for how human brain imaging studies of natural rewards and drugs of abuse are designed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBrain Imaging and Behavior
DOIs
StateAccepted/In press - Jan 26 2018

Fingerprint

Reward
Dopamine
Street Drugs
Neuroimaging
Brain
Pharmaceutical Preparations
Ventral Striatum
Learning
Research

Keywords

  • Addiction
  • Dopamine
  • fMRI
  • Motor
  • Nucleus accumbens
  • PET
  • Reward
  • Ventral striatum

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

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