Mitochondrial contribution to protein synthesis in cerebral cortex

H. R. Mahler, L. R. Jones, W. J. Moore

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Emetine (at 100 μg/ml) blocks the incorporation of 3H-leucine into the total protein of slices from rat cerebral cortex by > 95%; the block on the synthesis of cytosol proteins is quantitative. Under these conditions protein synthesis resistant to emetine is localized in a mitochondrial fraction that is sensitive to chloramphenicol at 100 μg/ml to the extent of ∼ 70%. We infer that some 15% of the proteins of cerebral cortex mitochondria formed during a 60 min period have been provided by their own protein synthesizing system.

Original languageEnglish (US)
Pages (from-to)384-389
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume42
Issue number3
DOIs
StatePublished - Feb 5 1971

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Mitochondrial contribution to protein synthesis in cerebral cortex'. Together they form a unique fingerprint.

  • Cite this