Mitochondrial DNA damage and its potential role in retinal degeneration

Stuart G. Jarrett, Haijiang Lin, Bernard F. Godley, Michael E. Boulton

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Mitochondria are central to retinal cell function and survival. There is increasing evidence to support an association between mitochondrial dysfunction and a number of retinal pathologies including age-related macular degeneration (AMD), diabetic retinopathy and glaucoma. The past decade has highlighted mitochondrial genomic instability as an important factor in mitochondrial impairment culminating in age-related changes and age-related pathology. This represents a combination of the susceptibility of mitochondrial DNA (mtDNA) to oxidative damage and a limited base excision repair pathway. This random cumulative mtDNA damage leads to cellular heteroplasmy and, if the damage affects a sufficient proportion of mitochondria within a given cell, results in loss of cell function and greater susceptibility to stress. mtDNA damage is increased in the neural retina and RPE with ageing and appears to be greatest in AMD. It thus appears that the mitochondrial genome is a weak link in the antioxidant defenses of retinal cells and that deficits in mitochondrial DNA (mtDNA) repair pathways are important contributors to the pathogenesis of retinal degeneration. Specifically targeting mitochondria with pharmacological agents able to protect against oxidative stress or promote repair of mtDNA damage may offer potential alternatives for the treatment of retinal degenerations such as AMD.

Original languageEnglish (US)
Pages (from-to)596-607
Number of pages12
JournalProgress in Retinal and Eye Research
Volume27
Issue number6
DOIs
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Retinal Degeneration
Mitochondrial DNA
DNA Damage
Macular Degeneration
Mitochondria
DNA Repair
Pathology
Mitochondrial Genome
Genomic Instability
Diabetic Retinopathy
Glaucoma
Retina
Cell Survival
Oxidative Stress
Antioxidants
Pharmacology

Keywords

  • Age-related macular degeneration
  • Base excision repair
  • Mitochondria
  • Oxidative stress
  • Retinal degeneration
  • Retinal pigment epithelium

ASJC Scopus subject areas

  • Sensory Systems
  • Ophthalmology

Cite this

Mitochondrial DNA damage and its potential role in retinal degeneration. / Jarrett, Stuart G.; Lin, Haijiang; Godley, Bernard F.; Boulton, Michael E.

In: Progress in Retinal and Eye Research, Vol. 27, No. 6, 11.2008, p. 596-607.

Research output: Contribution to journalArticle

Jarrett, Stuart G. ; Lin, Haijiang ; Godley, Bernard F. ; Boulton, Michael E. / Mitochondrial DNA damage and its potential role in retinal degeneration. In: Progress in Retinal and Eye Research. 2008 ; Vol. 27, No. 6. pp. 596-607.
@article{1df72b98520344d4b8d4a1b822e141e3,
title = "Mitochondrial DNA damage and its potential role in retinal degeneration",
abstract = "Mitochondria are central to retinal cell function and survival. There is increasing evidence to support an association between mitochondrial dysfunction and a number of retinal pathologies including age-related macular degeneration (AMD), diabetic retinopathy and glaucoma. The past decade has highlighted mitochondrial genomic instability as an important factor in mitochondrial impairment culminating in age-related changes and age-related pathology. This represents a combination of the susceptibility of mitochondrial DNA (mtDNA) to oxidative damage and a limited base excision repair pathway. This random cumulative mtDNA damage leads to cellular heteroplasmy and, if the damage affects a sufficient proportion of mitochondria within a given cell, results in loss of cell function and greater susceptibility to stress. mtDNA damage is increased in the neural retina and RPE with ageing and appears to be greatest in AMD. It thus appears that the mitochondrial genome is a weak link in the antioxidant defenses of retinal cells and that deficits in mitochondrial DNA (mtDNA) repair pathways are important contributors to the pathogenesis of retinal degeneration. Specifically targeting mitochondria with pharmacological agents able to protect against oxidative stress or promote repair of mtDNA damage may offer potential alternatives for the treatment of retinal degenerations such as AMD.",
keywords = "Age-related macular degeneration, Base excision repair, Mitochondria, Oxidative stress, Retinal degeneration, Retinal pigment epithelium",
author = "Jarrett, {Stuart G.} and Haijiang Lin and Godley, {Bernard F.} and Boulton, {Michael E.}",
year = "2008",
month = "11",
doi = "10.1016/j.preteyeres.2008.09.001",
language = "English (US)",
volume = "27",
pages = "596--607",
journal = "Progress in Retinal and Eye Research",
issn = "1350-9462",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Mitochondrial DNA damage and its potential role in retinal degeneration

AU - Jarrett, Stuart G.

AU - Lin, Haijiang

AU - Godley, Bernard F.

AU - Boulton, Michael E.

PY - 2008/11

Y1 - 2008/11

N2 - Mitochondria are central to retinal cell function and survival. There is increasing evidence to support an association between mitochondrial dysfunction and a number of retinal pathologies including age-related macular degeneration (AMD), diabetic retinopathy and glaucoma. The past decade has highlighted mitochondrial genomic instability as an important factor in mitochondrial impairment culminating in age-related changes and age-related pathology. This represents a combination of the susceptibility of mitochondrial DNA (mtDNA) to oxidative damage and a limited base excision repair pathway. This random cumulative mtDNA damage leads to cellular heteroplasmy and, if the damage affects a sufficient proportion of mitochondria within a given cell, results in loss of cell function and greater susceptibility to stress. mtDNA damage is increased in the neural retina and RPE with ageing and appears to be greatest in AMD. It thus appears that the mitochondrial genome is a weak link in the antioxidant defenses of retinal cells and that deficits in mitochondrial DNA (mtDNA) repair pathways are important contributors to the pathogenesis of retinal degeneration. Specifically targeting mitochondria with pharmacological agents able to protect against oxidative stress or promote repair of mtDNA damage may offer potential alternatives for the treatment of retinal degenerations such as AMD.

AB - Mitochondria are central to retinal cell function and survival. There is increasing evidence to support an association between mitochondrial dysfunction and a number of retinal pathologies including age-related macular degeneration (AMD), diabetic retinopathy and glaucoma. The past decade has highlighted mitochondrial genomic instability as an important factor in mitochondrial impairment culminating in age-related changes and age-related pathology. This represents a combination of the susceptibility of mitochondrial DNA (mtDNA) to oxidative damage and a limited base excision repair pathway. This random cumulative mtDNA damage leads to cellular heteroplasmy and, if the damage affects a sufficient proportion of mitochondria within a given cell, results in loss of cell function and greater susceptibility to stress. mtDNA damage is increased in the neural retina and RPE with ageing and appears to be greatest in AMD. It thus appears that the mitochondrial genome is a weak link in the antioxidant defenses of retinal cells and that deficits in mitochondrial DNA (mtDNA) repair pathways are important contributors to the pathogenesis of retinal degeneration. Specifically targeting mitochondria with pharmacological agents able to protect against oxidative stress or promote repair of mtDNA damage may offer potential alternatives for the treatment of retinal degenerations such as AMD.

KW - Age-related macular degeneration

KW - Base excision repair

KW - Mitochondria

KW - Oxidative stress

KW - Retinal degeneration

KW - Retinal pigment epithelium

UR - http://www.scopus.com/inward/record.url?scp=55649114157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55649114157&partnerID=8YFLogxK

U2 - 10.1016/j.preteyeres.2008.09.001

DO - 10.1016/j.preteyeres.2008.09.001

M3 - Article

C2 - 18848639

AN - SCOPUS:55649114157

VL - 27

SP - 596

EP - 607

JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

SN - 1350-9462

IS - 6

ER -