Mitogenic and suppressive activity of mycelia from gram-positive bacteria on murine and human lymphocytes

Bernhard Maier, D. P. Baron, H. Bockhorn, H. Drautz, J. Langhärig, W. G. Bessler

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mycelia from several strains of Streptomyces were potent B-lymphocyte mitogens for spleen cells from 3 inbred mouse strains (BALB/c, C3H/HeJ, C3H/nu/nu), inducing lymphocyte proliferation and differentiation into immunoglobulin-secreting cells. Streptomyces mycelia were also mitogenic towards human peripheral blood lymphocytes, where maximal stimulation was found on days 5 to 7. On the other hand, human lymphocytes incubated with the mycelia for 3 days, but not the supernatants of these cultures, strongly inhibited mixed leukocyte reactions. Irradiation experiments suggest the induction of both radioresistant and radiolabile suppressor-cell populations by the components.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalImmunobiology
Volume163
Issue number5
DOIs
StatePublished - 1982
Externally publishedYes

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Mycelium
Gram-Positive Bacteria
Streptomyces
Lymphocytes
Antibody-Producing Cells
Mixed Lymphocyte Culture Test
Inbred Strains Mice
Cellular Structures
Lymphocyte Activation
Mitogens
B-Lymphocytes
Spleen
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Mitogenic and suppressive activity of mycelia from gram-positive bacteria on murine and human lymphocytes. / Maier, Bernhard; Baron, D. P.; Bockhorn, H.; Drautz, H.; Langhärig, J.; Bessler, W. G.

In: Immunobiology, Vol. 163, No. 5, 1982, p. 427-435.

Research output: Contribution to journalArticle

Maier, Bernhard ; Baron, D. P. ; Bockhorn, H. ; Drautz, H. ; Langhärig, J. ; Bessler, W. G. / Mitogenic and suppressive activity of mycelia from gram-positive bacteria on murine and human lymphocytes. In: Immunobiology. 1982 ; Vol. 163, No. 5. pp. 427-435.
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