Mitogenic and Suppressive Activity of Mycelia from Gram-Positive Bacteria on Murine and Human Lymphocytes

B. F. Maier, D. P. Baron, H. Bockhorn, H. Drautz, J. Langhärig, W. G. Bessler

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Mycelia from several strains of Streptomyces were potent B-lymphocyte mitogens for spleen cells from 3 inbred mouse strains (BALB/c, C3H/HeJ, C3H/nu/nu), inducing lymphocyte proliferation and differentiation into immunoglobulin-secreting cells. Streptomyces mycelia were also mitogenic towards human peripheral blood lymphocytes, where maximal stimulation was found on days 5 to 7. On the other hand, human lymphocytes incubated with the mycelia for 3 days, but not the supernatants of these cultures, strongly inhibited mixed leukocyte reactions. Irradiation experiments suggest the induction of both radioresistant and radiolabile suppressor-cell populations by the components.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalImmunobiology
Volume163
Issue number5
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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