Mitogenic effect of a growth factor derived from myelin on denervated regenerates of newt forelimbs

Anthony Mescher, Denis Gospodarowicz

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Fibroblast growth factor injected into denervated early regenerates of adult newt forelimbs promotes mitotic activity in the dedifferentiated mesodermal cells. The effect is dose‐dependent and is not produced with similar doses of cytochrome c, bovine serum albumin, or growth hormone. Epidermal growth factor has a mitogenic effect less than half as great as that of fibroblast growth factor. The results suggest the possibility of a role for myel in‐derived growth factors in blastema formation.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalJournal of Experimental Zoology
Volume207
Issue number3
DOIs
StatePublished - 1979
Externally publishedYes

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fibroblast growth factors
myelin sheath
forelimbs
salamanders and newts
growth factors
cytochrome c
epidermal growth factor
bovine serum albumin
somatotropin
dosage
cells

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Mitogenic effect of a growth factor derived from myelin on denervated regenerates of newt forelimbs. / Mescher, Anthony; Gospodarowicz, Denis.

In: Journal of Experimental Zoology, Vol. 207, No. 3, 1979, p. 497-504.

Research output: Contribution to journalArticle

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