Mitotic spindle assembly and chromosome segregation: Refocusing on microtubule dynamics

Susan L. Kline-Smith, Claire E. Walczak

Research output: Contribution to journalReview article

216 Scopus citations

Abstract

The quest to find the underlying mechanisms of mitosis has taken many turns, which have largely been directed by the development of sensitive microscopes, enhanced microtubule-labeling techniques, advances in tubulin biochemistry, and genome-wide surveys to find the molecular "missing pieces" to the puzzle. Much of the work over the past decade has focused on the role of molecular motors in producing the necessary forces for spindle assembly and chromosome segregation. Recently, there has been a resurgence in research directed at understanding the intricate regulation of microtubule dynamics and organization during mitosis. This comes in part from the identification of new proteins involved in microtubule regulation as well as advances in fluorescence imaging that allow visualization of mitotic processes that previously have never been observed.

Original languageEnglish (US)
Pages (from-to)317-327
Number of pages11
JournalMolecular Cell
Volume15
Issue number3
DOIs
StatePublished - Aug 13 2004

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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