Mitotic spindle assembly and chromosome segregation

Refocusing on microtubule dynamics

Susan L. Kline-Smith, Claire Walczak

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

The quest to find the underlying mechanisms of mitosis has taken many turns, which have largely been directed by the development of sensitive microscopes, enhanced microtubule-labeling techniques, advances in tubulin biochemistry, and genome-wide surveys to find the molecular "missing pieces" to the puzzle. Much of the work over the past decade has focused on the role of molecular motors in producing the necessary forces for spindle assembly and chromosome segregation. Recently, there has been a resurgence in research directed at understanding the intricate regulation of microtubule dynamics and organization during mitosis. This comes in part from the identification of new proteins involved in microtubule regulation as well as advances in fluorescence imaging that allow visualization of mitotic processes that previously have never been observed.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalMolecular Cell
Volume15
Issue number3
DOIs
StatePublished - Aug 13 2004

Fingerprint

Chromosome Segregation
Spindle Apparatus
Microtubules
Mitosis
Optical Imaging
Tubulin
Biochemistry
Genome
Research
Proteins

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Mitotic spindle assembly and chromosome segregation : Refocusing on microtubule dynamics. / Kline-Smith, Susan L.; Walczak, Claire.

In: Molecular Cell, Vol. 15, No. 3, 13.08.2004, p. 317-327.

Research output: Contribution to journalArticle

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