Mitotic spindle assembly mechanisms

Rebecca Heald, Claire E. Walczak

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The mitotic spindle consists of dynamic microtubules and many associated factors that form an antiparallel, bipolar array. Duplicated chromosomes are attached to microtubules of the spindle and then are physically separated by the spindle to opposite ends of the dividing cell. Spindles vary in their morphology and assembly pathway depending on the cell type and organism, but common underlying mechanisms derive from the dynamics of the microtubules and microtubule-based motor proteins, and the activities of chromosomes themselves. In this chapter, we describe the multiple mechanisms that promote assembly of the dynamic mitotic spindle.

Original languageEnglish (US)
Title of host publicationThe Kinetochore
Subtitle of host publicationFrom Molecular Discoveries to Cancer Therapy
PublisherSpringer New York
Pages231-268
Number of pages38
ISBN (Print)9780387690735
DOIs
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Heald, R., & Walczak, C. E. (2009). Mitotic spindle assembly mechanisms. In The Kinetochore: From Molecular Discoveries to Cancer Therapy (pp. 231-268). Springer New York. https://doi.org/10.1007/978-0-387-69076-6_8