Abstract
MLL rearrangements in humans lead to both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). While AML has been successfully produced in mice, modeling ALL has been more difficult. In this issue of Cancer Cell, Wei et al. (2008) describe generation of AML, ALL, and biphenotypic leukemia by manipulating the cytokine milieu of human progenitor cells expressing MLL-AF9. They demonstrate that both multipotent and lineage-restricted progenitors are targeted by MLL-AF9 fusion proteins and that Rac signaling is crucial for survival. This study demonstrates the heterogeneity of MLL-AF9 leukemic stem cells and the importance of the microenvironment in determining lineage outcome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 465-467 |
| Number of pages | 3 |
| Journal | Cancer Cell |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 10 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Oncology
Cite this
MLL-AF9 Leukemia Stem Cells : Hardwired or Taking Cues from the Microenvironment? / Muntean, Andrew G.; Hess, Jay.
In: Cancer Cell, Vol. 13, No. 6, 10.06.2008, p. 465-467.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MLL-AF9 Leukemia Stem Cells
T2 - Hardwired or Taking Cues from the Microenvironment?
AU - Muntean, Andrew G.
AU - Hess, Jay
PY - 2008/6/10
Y1 - 2008/6/10
N2 - MLL rearrangements in humans lead to both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). While AML has been successfully produced in mice, modeling ALL has been more difficult. In this issue of Cancer Cell, Wei et al. (2008) describe generation of AML, ALL, and biphenotypic leukemia by manipulating the cytokine milieu of human progenitor cells expressing MLL-AF9. They demonstrate that both multipotent and lineage-restricted progenitors are targeted by MLL-AF9 fusion proteins and that Rac signaling is crucial for survival. This study demonstrates the heterogeneity of MLL-AF9 leukemic stem cells and the importance of the microenvironment in determining lineage outcome.
AB - MLL rearrangements in humans lead to both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). While AML has been successfully produced in mice, modeling ALL has been more difficult. In this issue of Cancer Cell, Wei et al. (2008) describe generation of AML, ALL, and biphenotypic leukemia by manipulating the cytokine milieu of human progenitor cells expressing MLL-AF9. They demonstrate that both multipotent and lineage-restricted progenitors are targeted by MLL-AF9 fusion proteins and that Rac signaling is crucial for survival. This study demonstrates the heterogeneity of MLL-AF9 leukemic stem cells and the importance of the microenvironment in determining lineage outcome.
UR - http://www.scopus.com/inward/record.url?scp=44449086493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449086493&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2008.05.012
DO - 10.1016/j.ccr.2008.05.012
M3 - Article
C2 - 18538728
AN - SCOPUS:44449086493
VL - 13
SP - 465
EP - 467
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 6
ER -