MLL core components give the green light to histone methylation.

Brendan D. Crawford, Jay Hess

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Trimethylation of histone H3 Lys4 (H3K4) is associated with transcriptional activation. One of the chief effectors of H3K4 methylation is mixed-lineage leukemia 1 (MLL1), a gene that is disrupted by chromosomal translocation in acute leukemia and a master regulator of Hox and other genes. In a recent paper, core components of the human MLL histone methyltransferase (MT) complex were found to form a structural platform, with one component (WDR5) mediating association between the specific histone H3K4 substrate and the MT. This novel regulatory mechanism, which is conserved from yeast to human, is required for both methylation and downstream target gene transcription.

Original languageEnglish (US)
Pages (from-to)495-498
Number of pages4
JournalACS Chemical Biology
Volume1
Issue number8
DOIs
StatePublished - Sep 19 2006
Externally publishedYes

Fingerprint

Methyl Green
Methylation
Histones
Leukemia
Genes
Genetic Translocation
Homeobox Genes
Methyltransferases
Transcriptional Activation
Yeasts
Transcription
Yeast
Chemical activation
Association reactions
Substrates
histone methyltransferase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

MLL core components give the green light to histone methylation. / Crawford, Brendan D.; Hess, Jay.

In: ACS Chemical Biology, Vol. 1, No. 8, 19.09.2006, p. 495-498.

Research output: Contribution to journalArticle

Crawford, Brendan D. ; Hess, Jay. / MLL core components give the green light to histone methylation. In: ACS Chemical Biology. 2006 ; Vol. 1, No. 8. pp. 495-498.
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