MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations

Yongmei Chen, Yongfeng Fan, K. Y Trudy Poon, Achal S. Achrol, Michael T. Lawton, Yiqian Zhu, Charles E. McCulloch, Tomoki Hashimoto, Chanhung Lee, Nicholas Barbaro, Andrew W. Bollen, Guo Yuan Yang, William L. Young

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Brain arteriovenous malformations (BAVM) have high matrix metalloproteinase-9 (MMP-9) expression, the source of which is unclear. We hypothesized MMP-9 production might be due to inflammation in BAVM. Compared to control brain tissues (n=5), BAVM tissue (n=139) had a higher expression (by ELISA) of myeloperoxidase (MPO) (193±189 vs. 6±3, ng/mg, P2=.76, P2=.32, P2=.03, P=.05), and CD31 (R2=.004, P= .57). Compared to non-embolized patients (n=46), patients with pre-operative embolization (n=93) had higher levels of myeloperoxidase (236±205 vs. 106±108, ng/mg, P2=.69, n=93, P

Original languageEnglish (US)
Pages (from-to)3121-3128
Number of pages8
JournalFrontiers in Bioscience
Volume11
Issue numberSUPPL. 3
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Arteriovenous Malformations
Matrix Metalloproteinase 9
Brain
Peroxidase
Encephalitis
Tissue
Enzyme-Linked Immunosorbent Assay

Keywords

  • Brain
  • Inflammation
  • Matrix metalloprotease-9
  • Myeloperoxidase
  • Vascular Malformations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Chen, Y., Fan, Y., Poon, K. Y. T., Achrol, A. S., Lawton, M. T., Zhu, Y., ... Young, W. L. (2006). MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. Frontiers in Bioscience, 11(SUPPL. 3), 3121-3128. https://doi.org/10.2741/2037

MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. / Chen, Yongmei; Fan, Yongfeng; Poon, K. Y Trudy; Achrol, Achal S.; Lawton, Michael T.; Zhu, Yiqian; McCulloch, Charles E.; Hashimoto, Tomoki; Lee, Chanhung; Barbaro, Nicholas; Bollen, Andrew W.; Yang, Guo Yuan; Young, William L.

In: Frontiers in Bioscience, Vol. 11, No. SUPPL. 3, 2006, p. 3121-3128.

Research output: Contribution to journalArticle

Chen, Y, Fan, Y, Poon, KYT, Achrol, AS, Lawton, MT, Zhu, Y, McCulloch, CE, Hashimoto, T, Lee, C, Barbaro, N, Bollen, AW, Yang, GY & Young, WL 2006, 'MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations', Frontiers in Bioscience, vol. 11, no. SUPPL. 3, pp. 3121-3128. https://doi.org/10.2741/2037
Chen, Yongmei ; Fan, Yongfeng ; Poon, K. Y Trudy ; Achrol, Achal S. ; Lawton, Michael T. ; Zhu, Yiqian ; McCulloch, Charles E. ; Hashimoto, Tomoki ; Lee, Chanhung ; Barbaro, Nicholas ; Bollen, Andrew W. ; Yang, Guo Yuan ; Young, William L. / MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. In: Frontiers in Bioscience. 2006 ; Vol. 11, No. SUPPL. 3. pp. 3121-3128.
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