Modeling alcohol self-administration in the human laboratory.

Ulrich S. Zimmermann, Sean O'Connor, Vijay A. Ramchandani

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This review focuses on 27 studies employing experimental alcohol self-administration (ASA) in humans which were published between 1989 and 2010. Twelve studies enrolling healthy, non-dependent social drinkers (HSD) were aimed at evaluating physiological and behavioral determinants of alcohol-induced reward or modeling situations of increased risk to develop alcohol use disorders. The remaining 15 studies tested the effect of medications such as naltrexone, nalmefene, nicotine, mecamylamine, varenicline, gabapentin, aripiprazole, and rimonabant on ASA. The participants were either HSD or non-treatment-seeking alcoholics (NTSA). In 25 of these studies, the subjects ingested alcohol orally and reached a mean peak blood alcohol concentration (BAC) during baseline conditions between 43 and 47 mg% (0.043-0.047%). Two recent studies employed computer-assisted self-infusion of ethanol (CASE), where subjects press a button to request multiple sequential alcohol exposures intravenously instead of drinking. This method has been demonstrated to be safe and provides increased experimental control of BAC and keeps subjects blind concerning the amount already self-administered. Peak exposures in the CASE studies ranged from 60 to 80 mg% in HSD and up to 240 mg% in NTSA.

Original languageEnglish
Pages (from-to)315-353
Number of pages39
JournalCurrent Topics in Behavioral Neurosciences
Volume13
DOIs
StatePublished - 2013

Fingerprint

Self Administration
Alcohols
rimonabant
Alcoholics
Ethanol
Mecamylamine
Naltrexone
Nicotine
Reward
Drinking

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Modeling alcohol self-administration in the human laboratory. / Zimmermann, Ulrich S.; O'Connor, Sean; Ramchandani, Vijay A.

In: Current Topics in Behavioral Neurosciences, Vol. 13, 2013, p. 315-353.

Research output: Contribution to journalArticle

Zimmermann, Ulrich S. ; O'Connor, Sean ; Ramchandani, Vijay A. / Modeling alcohol self-administration in the human laboratory. In: Current Topics in Behavioral Neurosciences. 2013 ; Vol. 13. pp. 315-353.
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