Modeling hemodynamic responses in auditory cortex at 1.5 T using variable duration imaging acoustic noise

Shuowen Hu, Olumide Olulade, Javier Gonzalez Castillo, Joseph Santos, Sungeun Kim, Gregory G. Tamer, Wen Ming Luh, Thomas M. Talavage

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A confound for functional magnetic resonance imaging (fMRI), especially for auditory studies, is the presence of imaging acoustic noise generated mainly as a byproduct of rapid gradient switching during volume acquisition and, to a lesser extent, the radiofrequency transmit. This work utilized a novel pulse sequence to present actual imaging acoustic noise for characterization of the induced hemodynamic responses and assessment of linearity in the primary auditory cortex with respect to noise duration. Results show that responses to brief duration (46 ms) imaging acoustic noise is highly nonlinear while responses to longer duration (>1 s) imaging acoustic noise becomes approximately linear, with the right primary auditory cortex exhibiting a higher degree of nonlinearity than the left for the investigated noise durations. This study also assessed the spatial extent of activation induced by imaging acoustic noise, showing that the use of modeled responses (specific to imaging acoustic noise) as the reference waveform revealed additional activations in the auditory cortex not observed with a canonical gamma variate reference waveform, suggesting an improvement in detection sensitivity for imaging acoustic noise-induced activity. Longer duration (1.5 s) imaging acoustic noise was observed to induce activity that expanded outwards from Heschl's gyrus to cover the superior temporal gyrus as well as parts of the middle temporal gyrus and insula, potentially affecting higher level acoustic processing.

Original languageEnglish (US)
Pages (from-to)3027-3038
Number of pages12
JournalNeuroImage
Volume49
Issue number4
DOIs
StatePublished - Feb 15 2010
Externally publishedYes

Fingerprint

Auditory Cortex
Acoustics
Noise
Hemodynamics
Temporal Lobe
Magnetic Resonance Imaging

Keywords

  • Functional MRI
  • Hemodynamic response
  • Imaging acoustic noise
  • Linear systems

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Hu, S., Olulade, O., Castillo, J. G., Santos, J., Kim, S., Tamer, G. G., ... Talavage, T. M. (2010). Modeling hemodynamic responses in auditory cortex at 1.5 T using variable duration imaging acoustic noise. NeuroImage, 49(4), 3027-3038. https://doi.org/10.1016/j.neuroimage.2009.11.051

Modeling hemodynamic responses in auditory cortex at 1.5 T using variable duration imaging acoustic noise. / Hu, Shuowen; Olulade, Olumide; Castillo, Javier Gonzalez; Santos, Joseph; Kim, Sungeun; Tamer, Gregory G.; Luh, Wen Ming; Talavage, Thomas M.

In: NeuroImage, Vol. 49, No. 4, 15.02.2010, p. 3027-3038.

Research output: Contribution to journalArticle

Hu, S, Olulade, O, Castillo, JG, Santos, J, Kim, S, Tamer, GG, Luh, WM & Talavage, TM 2010, 'Modeling hemodynamic responses in auditory cortex at 1.5 T using variable duration imaging acoustic noise', NeuroImage, vol. 49, no. 4, pp. 3027-3038. https://doi.org/10.1016/j.neuroimage.2009.11.051
Hu, Shuowen ; Olulade, Olumide ; Castillo, Javier Gonzalez ; Santos, Joseph ; Kim, Sungeun ; Tamer, Gregory G. ; Luh, Wen Ming ; Talavage, Thomas M. / Modeling hemodynamic responses in auditory cortex at 1.5 T using variable duration imaging acoustic noise. In: NeuroImage. 2010 ; Vol. 49, No. 4. pp. 3027-3038.
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