Modeling hot flushes and quality of life in breast cancer survivors

K. L. Rand, Julie Otte, D. Flockhart, D. Hayes, Anna Maria Storniolo, V. Stearns, N. L. Henry, A. Nguyen, S. Lemler, J. Hayden, S. Jeter, Janet Carpenter

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objectives To evaluate the relationships among measures of hot flushes, perceived hot flush interference, sleep disturbance, and measures of quality of life while controlling for potential covariates (patient and treatment variables). Methods Breast cancer survivors (n=395) due to receive aromatase inhibitor therapy provided demographic information, physiological hot flush data via sternal skin conductance monitoring, hot flush frequency via written diary and electronic event marker, hot flush severity and bother via written diary, and questionnaire data via the Hot Flash Related Daily Interference Scale, Pittsburgh Sleep Quality Index, the EuroQOL, Hospital Anxiety and Depression Scale and the Center for Epidemiologic Studies Depression Scale. Results Confirmatory factor analysis supported a two-factor model for hot flush symptoms (frequency and severity). Although there was strong convergence among self-reported hot flush measures, there was a high degree of unexplained variance associated with physiological measures. This suggests that self-report and physiological measures do not overlap substantially. The structural model showed that greater hot flush frequency and severity were directly related to greater perceived interference with daily life activities. Greater perceived interference, in turn, directly predicted greater sleep disruption, which predicted lower perceived health state and more symptoms of anxiety and depression. Conclusions Findings suggest hot flush interference may be the most appropriate single measure to include in clinical trials of vasomotor symptom therapies. Measuring and ameliorating patients' perceptions of hot flush interference with life activities and subjective sleep quality may be the most direct routes to improving quality of life.

Original languageEnglish
Pages (from-to)171-180
Number of pages10
JournalClimacteric
Volume14
Issue number1
DOIs
StatePublished - Feb 2011

Fingerprint

Survivors
Sleep
Quality of Life
Breast Neoplasms
Depression
Anxiety
Hot Flashes
Aromatase Inhibitors
Structural Models
Self Report
Statistical Factor Analysis
Epidemiologic Studies
Therapeutics
Demography
Clinical Trials
Skin
Health

Keywords

  • breast cancer
  • Hot flushes
  • menopause
  • quality of life
  • structural model

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Modeling hot flushes and quality of life in breast cancer survivors. / Rand, K. L.; Otte, Julie; Flockhart, D.; Hayes, D.; Storniolo, Anna Maria; Stearns, V.; Henry, N. L.; Nguyen, A.; Lemler, S.; Hayden, J.; Jeter, S.; Carpenter, Janet.

In: Climacteric, Vol. 14, No. 1, 02.2011, p. 171-180.

Research output: Contribution to journalArticle

Rand, KL, Otte, J, Flockhart, D, Hayes, D, Storniolo, AM, Stearns, V, Henry, NL, Nguyen, A, Lemler, S, Hayden, J, Jeter, S & Carpenter, J 2011, 'Modeling hot flushes and quality of life in breast cancer survivors', Climacteric, vol. 14, no. 1, pp. 171-180. https://doi.org/10.3109/13697131003717070
Rand, K. L. ; Otte, Julie ; Flockhart, D. ; Hayes, D. ; Storniolo, Anna Maria ; Stearns, V. ; Henry, N. L. ; Nguyen, A. ; Lemler, S. ; Hayden, J. ; Jeter, S. ; Carpenter, Janet. / Modeling hot flushes and quality of life in breast cancer survivors. In: Climacteric. 2011 ; Vol. 14, No. 1. pp. 171-180.
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