Modeling of bone failure by cohesive zone models

Thomas Siegmund, Matthew R. Allen, David B. Burr

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Cohesive zone models are a powerful tool for investigations of non-linear deformation and failure processes. For the nanoscale, the use of cohesive zone models is particularly attractive as the ratio of interface to volume is high, and because locally acting bonds between material components can become relevant. The present paper demonstrates the relevance of cohesive zone modelling approaches to the development of a nano-mechanical composite model of the mineralized collagen fibril, a fundamental building block of bone. As difficulties exist in determining the independent biomechan-ical effects of collagen cross-linking using in vitro and in vivo experiments, computational modeling can provide insight into the nanoscale processes. Stress-strain curves for mineralized collagen fibrils were obtained under tensile loading for various collagen cross-linking conditions. Our model predicts that the elastic deformation mode, the yield response and the final failure of the mineralized collagen fibril may depend significantly on the state of collagen cross-linking.

Original languageEnglish (US)
Title of host publicationMechanics Down Under - Proceedings of the 22nd International Congress of Theoretical and Applied Mechanics, ICTAM 2008
Pages217-230
Number of pages14
DOIs
StatePublished - Sep 11 2013
Event22nd International Congress of Theoretical and Applied Mechanics, ICTAM 2008 - Adelaide, SA, Australia
Duration: Aug 24 2008Aug 29 2008

Publication series

NameMechanics Down Under - Proceedings of the 22nd International Congress of Theoretical and Applied Mechanics, ICTAM 2008

Other

Other22nd International Congress of Theoretical and Applied Mechanics, ICTAM 2008
CountryAustralia
CityAdelaide, SA
Period8/24/088/29/08

ASJC Scopus subject areas

  • Mechanics of Materials

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    Siegmund, T., Allen, M. R., & Burr, D. B. (2013). Modeling of bone failure by cohesive zone models. In Mechanics Down Under - Proceedings of the 22nd International Congress of Theoretical and Applied Mechanics, ICTAM 2008 (pp. 217-230). (Mechanics Down Under - Proceedings of the 22nd International Congress of Theoretical and Applied Mechanics, ICTAM 2008). https://doi.org/10.1007/978-94-007-5968-8_14