Modeling traumatic brain injury using a compressed-gas blast chamber

Sean Connell, Michael Walls, Xiang Gao, Abeje Ambaw, Liang Chen, Jinhui Chen, Riyi Shi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Blast-induced neurotrauma (BINT) is a common injury modality associated with the current war efforts and increasing levels of terrorist activity. Exposure to the primary blast wave generated by explosive devices causes significant neurological deficits and is responsible for many of the war related pathologies. Despite research efforts, the mechanism of injury is still poorly understood. To this end, we have developed a pressure-driven blast wave generator to analyze the effects of mild blast exposure (500 kilopascals) on rats. This study provides novel evidence linking blast exposure to cellular degeneration in cortical tissue in the absence of functional behavioral deficits. This evidence of degeneration alongside visible hemorrhaging emphasizes the susceptibility of the central nervous system to impulse-like pressure wave insults. Furthermore, such study also highlighted the importance of diagnosing mild brain trauma to recognize, confirm, and treat such conditions in a timely fashion to prevent more severe injury over the time.

Original languageEnglish (US)
Title of host publicationProceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Pages969-972
Number of pages4
DOIs
StatePublished - Dec 1 2011
Event2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011 - Shanghai, China
Duration: Oct 15 2011Oct 17 2011

Publication series

NameProceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Volume2

Other

Other2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
CountryChina
CityShanghai
Period10/15/1110/17/11

Keywords

  • Blast
  • Neurotrauma
  • Pressure Wave
  • TBI

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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  • Cite this

    Connell, S., Walls, M., Gao, X., Ambaw, A., Chen, L., Chen, J., & Shi, R. (2011). Modeling traumatic brain injury using a compressed-gas blast chamber. In Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011 (pp. 969-972). [6098441] (Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011; Vol. 2). https://doi.org/10.1109/BMEI.2011.6098441