Modelling breast cancer: One size does not fit all

Tracy Vargo-Gogola, Jeffrey M. Rosen

Research output: Contribution to journalReview article

409 Scopus citations


Breast cancer is not a single disease, but is instead a collection of diseases that have distinct histopathological features, genetic and genomic variability, and diverse prognostic outcomes. Thus, no individual model would be expected to completely recapitulate this complex disease. Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?

Original languageEnglish (US)
Pages (from-to)659-672
Number of pages14
JournalNature Reviews Cancer
Issue number9
StatePublished - Sep 1 2007


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this