Models and signal processing for an implanted ethanol bio-sensor

Jae Joon Han, Peter C. Doerschuk, Saul B. Gelfand, Sean J. O'Connor

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The understanding of drinking patterns leading to alcoholism has been hindered by an inability to unobtrusively measure ethanol consumption over periods of weeks to months in the community environment. An implantable ethanol sensor is under development using microelectromechanical systems technology. For safety and user acceptability issues, the sensor will be implanted subcutaneously and, therefore, measure peripheral-tissue ethanol concentration. Determining ethanol consumption and kinetics in other compartments from the time course of peripheral-tissue ethanol concentration requires sophisticated signal processing based on detailed descriptions of the relevant physiology. A statistical signal processing system based on detailed models of the physiology and using extended Kalman filtering and dynamic programming tools is described which can estimate the time series of ethanol concentration in blood, liver, and peripheral tissue and the time series of ethanol consumption based on peripheral-tissue ethanol concentration measurements.

Original languageEnglish (US)
Pages (from-to)603-613
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Volume55
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Bio-sensor
  • Dynamic programming
  • Ethanol consumption model
  • Ethanol PBPK model
  • Ethanol pharmacokinetics model
  • Extended Kalman smoothing

ASJC Scopus subject areas

  • Biomedical Engineering

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