Models of inflammation: Carrageenan- or unit 5.4 complete freund's adjuvant (CFA)-induced edema and hypersensitivity in the rat

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Abstract

Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. This unit details methods to elicit and measure carrageenan- and complete Freund's adjuvant (CFA)-induced cutaneous inflammation. Due to possible differences between the dorsal root sensory system and the trigeminal sensory system, injections of either the footpad or vibrissal pad are described. In this manner, cutaneous inflammation can be assessed in tissue innervated by the lumbar dorsal root ganglion neurons (footpad) and by the trigeminal ganglion neurons (vibrissal pad).

Original languageEnglish
Article number5.4
JournalCurrent Protocols in Pharmacology
Issue numberSUPPL.56
DOIs
StatePublished - Mar 2012

Fingerprint

Freund's Adjuvant
Carrageenan
Edema
Hypersensitivity
Inflammation
Skin
Anti-Inflammatory Agents
Neurons
Trigeminal Ganglion
Spinal Nerve Roots
Spinal Ganglia
Analgesics
Animal Models
Injections
Pharmaceutical Preparations

Keywords

  • Carrageenan
  • Complete Freund's adjuvant
  • Edema
  • Inflammation
  • Nociception

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

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abstract = "Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. This unit details methods to elicit and measure carrageenan- and complete Freund's adjuvant (CFA)-induced cutaneous inflammation. Due to possible differences between the dorsal root sensory system and the trigeminal sensory system, injections of either the footpad or vibrissal pad are described. In this manner, cutaneous inflammation can be assessed in tissue innervated by the lumbar dorsal root ganglion neurons (footpad) and by the trigeminal ganglion neurons (vibrissal pad).",
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