Modified synthesis and antiangiogenic activity of Linomide

Saeed R. Khan, Annastasiah Mhaka, Roberto Pili, John T. Isaacs

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

Original languageEnglish (US)
Pages (from-to)451-452
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number4
DOIs
StatePublished - Feb 26 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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