Modified synthesis and antiangiogenic activity of Linomide

Saeed R. Khan, Annastasiah Mhaka, Roberto Pili, John T. Isaacs

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

Original languageEnglish (US)
Pages (from-to)451-452
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number4
DOIs
StatePublished - Feb 26 2001
Externally publishedYes

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Thermodynamic properties
Blood vessels
Microvessels
Blood Volume
Blood Vessels
Assays
Blood
Pharmaceutical Preparations
roquinimex

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Modified synthesis and antiangiogenic activity of Linomide. / Khan, Saeed R.; Mhaka, Annastasiah; Pili, Roberto; Isaacs, John T.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 4, 26.02.2001, p. 451-452.

Research output: Contribution to journalArticle

Khan, Saeed R. ; Mhaka, Annastasiah ; Pili, Roberto ; Isaacs, John T. / Modified synthesis and antiangiogenic activity of Linomide. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 4. pp. 451-452.
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