Modular regulation of muscle gene transcription: A mechanism for muscle cell diversity

Anthony B. Firulli, Eric N. Olson

Research output: Contribution to journalReview article

107 Scopus citations

Abstract

Skeletal, cardiac and smooth muscle cells express overlapping sets of muscle-specific genes, such that some muscle genes are expressed in only a single muscle cell type, whereas others are expressed in multiple muscle celt lineages. Recent studies in transgenic mice have revealed that, in many cases, multiple, independent cis-regulatory regions, or modules, are required to direct the complete developmental pattern of expression of individual muscle-specific genes, even within a single muscle cell type. The temporospatial specificity of these myogenic regulatory modules is established by unique combinations of transcription factors and has revealed unanticipated diversity in the regulatory programs that control muscle gene expression. This type of composite regulation of muscle gene expression appears to reflect a general strategy for the control of cell-specific gene expression.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalTrends in Genetics
Volume13
Issue number9
DOIs
StatePublished - Sep 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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