Modulation of anxiety circuits by serotonergic systems

Christopher A. Lowry, Philip Johnson, Anders Hay-Schmidt, Jens Mikkelsen, Anantha Shekhar

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

Original languageEnglish
Pages (from-to)233-246
Number of pages14
JournalStress
Volume8
Issue number4
DOIs
StatePublished - Dec 2005

Fingerprint

Anxiety
Avoidance Learning
Risk-Taking
Arousal
Brain Stem
Uncertainty

Keywords

  • 5-HT
  • 5-Hydroxytryptamine
  • Anxiety
  • Basolateral amygdala
  • Dorsal raphe nucleus
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Modulation of anxiety circuits by serotonergic systems. / Lowry, Christopher A.; Johnson, Philip; Hay-Schmidt, Anders; Mikkelsen, Jens; Shekhar, Anantha.

In: Stress, Vol. 8, No. 4, 12.2005, p. 233-246.

Research output: Contribution to journalArticle

Lowry, Christopher A. ; Johnson, Philip ; Hay-Schmidt, Anders ; Mikkelsen, Jens ; Shekhar, Anantha. / Modulation of anxiety circuits by serotonergic systems. In: Stress. 2005 ; Vol. 8, No. 4. pp. 233-246.
@article{4963737ad50e4775849b98b054da0bcd,
title = "Modulation of anxiety circuits by serotonergic systems",
abstract = "Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.",
keywords = "5-HT, 5-Hydroxytryptamine, Anxiety, Basolateral amygdala, Dorsal raphe nucleus, Serotonin",
author = "Lowry, {Christopher A.} and Philip Johnson and Anders Hay-Schmidt and Jens Mikkelsen and Anantha Shekhar",
year = "2005",
month = "12",
doi = "10.1080/10253890500492787",
language = "English",
volume = "8",
pages = "233--246",
journal = "Stress",
issn = "1025-3890",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Modulation of anxiety circuits by serotonergic systems

AU - Lowry, Christopher A.

AU - Johnson, Philip

AU - Hay-Schmidt, Anders

AU - Mikkelsen, Jens

AU - Shekhar, Anantha

PY - 2005/12

Y1 - 2005/12

N2 - Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

AB - Anxiety is a complex emotional state associated with sustained heightened autonomic and behavioral arousal and an increase in avoidance behavior. Anxiety-related behavior is a form of risk assessment behavior that is associated with a level of uncertainty or unpredictability regarding the outcome of emotionally salient events, often when both rewarding and aversive outcomes are possible. In this review, we highlight recent advances in our understanding of the neural circuits regulating anxiety states and anxiety-related behavior with an emphasis on the role of brainstem serotonergic systems in modulating anxiety-related circuits. In particular, we explore the possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocortical serotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus.

KW - 5-HT

KW - 5-Hydroxytryptamine

KW - Anxiety

KW - Basolateral amygdala

KW - Dorsal raphe nucleus

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=31544450567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31544450567&partnerID=8YFLogxK

U2 - 10.1080/10253890500492787

DO - 10.1080/10253890500492787

M3 - Article

C2 - 16423712

AN - SCOPUS:31544450567

VL - 8

SP - 233

EP - 246

JO - Stress

JF - Stress

SN - 1025-3890

IS - 4

ER -