Modulation of the Host's Immune Response to Plasmodium berghei by a Parasite‐Derived Immunosuppressive Factor

EDWARD F. SROUR, MARIANGELA SEGRE, DIEGO SEGRE

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Abstract

ABSTRACT. It is well known that Plasmodium‐infected hosts are immunosuppressed, as shown by their depressed immune responsiveness to a variety of antigens. It is not known, however, whether the immune response of malaria‐infected animals to the malarial parasite itself is suppressed. The availability of a noninfectious, immunosuppressive factor (ISF) derived from Plasmodium berghei‐infected rat erythrocytes made it possible to investigate this question. Mice infected with P. berghei and injected with the ISF had higher levels of parasitemia and shorter survival times than control mice that were similarly infected but were treated with control material derived from noninfected rat erythrocytes or with saline solution. Conversely, mice immunized against the ISF and then infected with P. berghei had lower parasitemias and longer survival times than mice immunized with the control material or with saline solution. We conclude that immunosuppression in murine malaria affects the course of malaria infection.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalThe Journal of Protozoology
Volume36
Issue number4
DOIs
StatePublished - Jul 1989

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Keywords

  • Erythrocytes
  • immunosuppression
  • macrophages
  • malaria

ASJC Scopus subject areas

  • Parasitology

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