Modulation of the Q-T interval by the autonomic nervous system.

K. F. Browne, E. Prystowsky, J. J. Heger, D. P. Zipes

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Recent investigations have clarified some of the effects of the autonomic nervous system on duration and spatial distribution of the Q-T interval in humans. The use of atrial pacing to fix heart rate or 24-hour continuous electrocardiographic recording to develop a regression formula for individual patients has provided a means to interpret the effects of an intervention that alters both the heart rate and the Q-T interval. Drugs that affect the autonomic nervous system can influence Q-T interval directly or by changing rate. Bazett's formula to correct for rate may be misleading after certain drug interventions. For example, the Q-T interval during sinus rhythm or atrial pacing and the ventricular effective refractory period shorten after atropine plus propranolol, but corrected Q-T interval using Bazett's formula does not change. No change occurs in the Q-T interval during sinus rhythm or atrial pacing, or in ventricular effective refractory period after administration of propranolol although corrected Q-T interval using Bazett's formula markedly shortens. Q-T interval during sinus rhythm and atrial pacing and ventricular effective refractory period decrease after atropine but correct Q-T interval lengthens.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)1050-1056
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Volume6
Issue number5 Pt 2
StatePublished - Sep 1983
Externally publishedYes

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Autonomic Nervous System
Atropine
Propranolol
Heart Rate
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Browne, K. F., Prystowsky, E., Heger, J. J., & Zipes, D. P. (1983). Modulation of the Q-T interval by the autonomic nervous system. PACE - Pacing and Clinical Electrophysiology, 6(5 Pt 2), 1050-1056.

Modulation of the Q-T interval by the autonomic nervous system. / Browne, K. F.; Prystowsky, E.; Heger, J. J.; Zipes, D. P.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 6, No. 5 Pt 2, 09.1983, p. 1050-1056.

Research output: Contribution to journalArticle

Browne, KF, Prystowsky, E, Heger, JJ & Zipes, DP 1983, 'Modulation of the Q-T interval by the autonomic nervous system.', PACE - Pacing and Clinical Electrophysiology, vol. 6, no. 5 Pt 2, pp. 1050-1056.
Browne KF, Prystowsky E, Heger JJ, Zipes DP. Modulation of the Q-T interval by the autonomic nervous system. PACE - Pacing and Clinical Electrophysiology. 1983 Sep;6(5 Pt 2):1050-1056.
Browne, K. F. ; Prystowsky, E. ; Heger, J. J. ; Zipes, D. P. / Modulation of the Q-T interval by the autonomic nervous system. In: PACE - Pacing and Clinical Electrophysiology. 1983 ; Vol. 6, No. 5 Pt 2. pp. 1050-1056.
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