Modulation of the Q‐T Interval by the Autonomic Nervous System

KEVIN F. BROWNE, ERIC PRYSTOWSKY, JAMES J. HEGER, DOUGLAS P. ZIPES

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Abstract

Recent investigations have clarified some of the effects of the autonomic nervous system on duration and spatial distribution of the Q-T interval in humans. The use of atrial pacing to fix heart rate or 24-hour continuous electrocardiographic recording to develop a regression formula for individual patients has provided a means to interpret the effects of an intervention that alters both the heart rate and the Q-T interval. Drugs that affect the autonomic nervous system can influence Q-T interval directly or by changing rate. Bazett's formula to correct for rate may be misleading after certain drug interventions. For example, the Q-T interval during sinus rhythm or atrial pacing and the ventricular effective refractory period shorten after atropine plus propranolol, but corrected Q-T interval using Bazett's formula does not change. No change occurs in the Q-T interval during sinus rhythm or atrial pacing, or in ventricular effective refractory period after administration of propranolol although corrected Q-T interval using Bazett's formula markedly shortens. Q-T interval during sinus rhythm and atrial pacing and ventricular effective refractory period decrease after atropine but correct Q-T interval lengthens.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)1050-1056
Number of pages7
JournalPacing and Clinical Electrophysiology
Volume6
Issue number5
DOIs
StatePublished - Sep 1983

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Keywords

  • Q‐T interval
  • arrhythmias
  • autonomic nervous system
  • humans

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

BROWNE, KEVIN. F., PRYSTOWSKY, ERIC., HEGER, JAMES. J., & ZIPES, DOUGLAS. P. (1983). Modulation of the Q‐T Interval by the Autonomic Nervous System. Pacing and Clinical Electrophysiology, 6(5), 1050-1056. https://doi.org/10.1111/j.1540-8159.1983.tb04443.x