Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms

Liang Cheng, Shaobo Zhang, Gregory T. MacLennan, Antonio Lopez-Beltran, Rodolfo Montironi

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Renal cell carcinomas comprise a heterogeneous group of epithelial neoplasms with diverse biologic potential and variable clinical outcomes. The application of molecular and cytogenetic techniques to the study of renal neoplasms has improved our understanding of the molecular mechanisms responsible for tumor initiation and progression. Molecular classification of renal cell carcinomas has also provided new avenues for diagnosis, clinical outcome, and therapy response prediction. In this article, we review the molecular markers for various renal epithelial neoplasms and discuss the mechanisms underlying the development of these neoplasms. We also evaluate the use of molecular and cytogenetic techniques in establishing an accurate diagnosis in difficult cases and their potential usefulness in accurately classifying renal neoplasms, assessing prognosis, and selecting appropriate therapy.

Original languageEnglish (US)
Pages (from-to)10-29
Number of pages20
JournalHuman pathology
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Classifications
  • Gene expression profiling differential diagnosis
  • Kidney
  • Molecular genetics
  • Molecular pathology
  • Renal neoplasms
  • Tumor origin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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